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GM-CSF-DT immunotoxin (CAT#: AGTO-L008D)

This immunotoxin was achieved by conjugating/fusing the Granulocyte-Macrophage Colony-Stimulating Factor to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to malignant or differentiated myeloid cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of acute myeloid leukemia (AML).


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Normal Tissue
Figure 1 IHC staining of human skin
Figure 1 IHC staining of human skin
(Immunohistochemical staining of human skin shows distinct cytoplasmic positivity in epidermal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/ihc_selected.jpg
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_B_9_5.jpg
Figure 3 Colon
Figure 3 Colon
(Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_7_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_8_5.jpg
Figure 5 Testis
Figure 5 Testis
(Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_6_6.jpg
Figure 6 Placenta
Figure 6 Placenta
(Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_3_7.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (BEWO, HMC-1, SK-MEL-30)
Figure 8 RNA cell line category: Group enriched (BEWO, HMC-1, SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198223-CSF2RA

Specifications

  • Host Species
  • Human
  • Species Reactivity
  • Human
  • Molecule Class
  • GM-CSF-DT
  • Toxin Description
  • Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Acute myeloid leukemia (AML)

Target

  • Alternative Names
  • GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha; Acute myeloid leukemia; AML; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB389

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CSF2RA"

Recombinant Antibody

CAT Product Name Application Type
MOB-2501z Mouse Anti-CSF2RA Recombinant Antibody (clone 23G1) WB, FC, IHC, IP Mouse IgG1
PABL-106 Human Anti-CSF2RA Recombinant Antibody (PABL-106) WB, Neut, FuncS Human IgG
PABL-107 Human Anti-CSF2RA Recombinant Antibody (PABL-107) WB, Neut, FuncS Human IgG
PABL-108 Human Anti-CSF2RA Recombinant Antibody (PABL-108) WB, Neut, FuncS Human IgG
PABL-109 Human Anti-CSF2RA Recombinant Antibody (PABL-109) Neut, FuncS Human IgG

scFv Fragment Antibody

CAT Product Name Application Type
PSBL-106 Human Anti-CSF2RA Recombinant Antibody; scFv Fragment (PSBL-106) WB, Neut, FuncS Human scFv
PSBL-107 Human Anti-CSF2RA Recombinant Antibody; scFv Fragment (PSBL-107) WB, Neut, FuncS Human scFv
PSBL-108 Human Anti-CSF2RA Recombinant Antibody; scFv Fragment (PSBL-108) WB, Neut, FuncS Human scFv
PSBL-109 Human Anti-CSF2RA Recombinant Antibody; scFv Fragment (PSBL-109) Neut, FuncS Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
PFBL-106 Human Anti-CSF2RA Recombinant Antibody; Fab Fragment (PFBL-106) WB, Neut, FuncS Human Fab
PFBL-107 Human Anti-CSF2RA Recombinant Antibody; Fab Fragment (PFBL-107) WB, Neut, FuncS Human Fab
PFBL-108 Human Anti-CSF2RA Recombinant Antibody; Fab Fragment (PFBL-108) WB, Neut, FuncS Human Fab
PFBL-109 Human Anti-CSF2RA Recombinant Antibody; Fab Fragment (PFBL-109) Neut, FuncS Human Fab

Neutralizing Antibody

CAT Product Name Application Type
NEUT-533CQ Rat Anti-Csf2ra Recombinant Antibody (clone CBL639) FC, CyTOF®, ICC, Neut Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0826 Hi-Affi™ Rabbit Anti-CSF2RA Recombinant Antibody (clone DS826AB) WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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