GM-CSF-DT immunotoxin (AGTO-L008D)
This immunotoxin was achieved by conjugating/fusing the Granulocyte-Macrophage Colony-Stimulating Factor to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to malignant or differentiated myeloid cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of acute myeloid leukemia (AML).
Specifications
- Host
- Human
- Species Reactivity
- Human
- Molecule Class
- GM-CSF-DT
- Toxin Description
- Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Acute myeloid leukemia (AML)
Target
- Alternative Names
- GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR
- Entrez Gene ID
- 1438
- UniProt ID
- P15509
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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