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    GM-CSF-DT immunotoxin (CAT#: AGTO-L008D)

    This immunotoxin was achieved by conjugating/fusing the Granulocyte-Macrophage Colony-Stimulating Factor to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to malignant or differentiated myeloid cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of acute myeloid leukemia (AML).

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    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 IHC staining of human skin
    Figure 1 IHC staining of human skin
    (Immunohistochemical staining of human skin shows distinct cytoplasmic positivity in epidermal cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/ihc_selected.jpg
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_B_9_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_7_3.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_8_5.jpg
    Figure 5 Testis
    Figure 5 Testis
    (Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_6_6.jpg
    Figure 6 Placenta
    Figure 6 Placenta
    (Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_3_7.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_9_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Group enriched (BEWO, HMC-1, SK-MEL-30)
    Figure 8 RNA cell line category: Group enriched (BEWO, HMC-1, SK-MEL-30)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198223-CSF2RA

    Specifications

    • Host Species
    • Human
    • Species Reactivity
    • Human
    • Molecule Class
    • GM-CSF-DT
    • Toxin Description
    • Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
    • Applications
    • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
    • Related Disease
    • Acute myeloid leukemia (AML)

    Target

    • Alternative Names
    • GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha; Acute myeloid leukemia; AML; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB389

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    See other products for "CSF2RA"

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    MOB-2501z Mouse Anti-CSF2RA Recombinant Antibody (clone 23G1) WB, FC, IHC, IP Mouse IgG1
    PABL-106 Human Anti-CSF2RA Recombinant Antibody (PABL-106) WB, Neut, FuncS Human IgG
    PABL-107 Human Anti-CSF2RA Recombinant Antibody (PABL-107) WB, Neut, FuncS Human IgG
    PABL-108 Human Anti-CSF2RA Recombinant Antibody (PABL-108) WB, Neut, FuncS Human IgG
    PABL-109 Human Anti-CSF2RA Recombinant Antibody (PABL-109) Neut, FuncS Human IgG

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