Human Anti-EPHA3 (clone KB004) scFv-Fc Chimera (CAT#: VS-0425-FY104)

• Immunogen
• LK63 cells as an immunogen.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human EPHA3

• Species Reactivity
• Human

• Clone
• KB004

• Applications
• ADCC

• Related Disease
• Hematologic Cancer and Glioma Susceptibility 1

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• EPH Receptor A3; Tyrosine-Protein Kinase Receptor ETK1; Eph-Like Tyrosine Kinase 1; EPH-Like Kinase 4; EC 2.7.10.1; TYRO4; HEK4; ETK1; ETK; EK4

• Gene ID
• 2042

• UniProt ID
• P29320

• Long Name
• EPH Receptor A3

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

• Cellular Localization
• Cell membrane, Secreted

• Post Translation Modifications
• Autophosphorylates upon activation by EFNA5.
  Phosphorylation on Tyr-602 mediates interaction with NCK1.
  Dephosphorylated by PTPN1.
  Glycosylation at Asn232, Asn337, Asn391, Asn404, and Asn493
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 7 sites, 3 N-linked glycans (3 sites)

• Protein Refseq
• XP_005264772.1; XP_047303629.1; XP_054201630.1; XP_054201631.1; NP_001397707.1

• Function
• Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
  Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5.
  Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration.
  Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1.
  Involved in the retinotectal mapping of neurons.
  May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

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