Human Anti-NOTCH2 scFv-Fc Chimera (VS-0425-FY160)
CAT#: VS-0425-FY160
Similar to NOTCH1, NOTCH2 is another member of the NOTCH family of receptors with crucial roles in development and disease. It is involved in processes like B cell development and Notch signaling pathways. This scFv-FC can be used to target NOTCH2 for research or therapeutic purposes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/714_F8_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Sertoli cells Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134250-NOTCH2
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Specifications
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human NOTCH2
- Species Reactivity
- Human
- Applications
- ELISA, Blocking, Western Blot
- Related Disease
- Alagille Syndrome 2 and Hajdu-Cheney Syndrome
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Notch 2; HN2; Neurogenic Locus Notch Homolog Protein 2; Notch (Drosophila) Homolog 2; Notch Homolog 2 (Drosophila); Notch Homolog 2; HJCYS; AGS2
- Gene ID
- 4853
- UniProt ID
- Q04721
- Long Name
- Notch 2
- Sequence Similarities
- Belongs to the NOTCH family.
- Cellular Localization
- Cell membrane, Nucleus, Cytoplasm
- Post Translation Modifications
- Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form.
Hydroxylated by HIF1AN.
Can be either O-glucosylated or O-xylosylated at Ser-613 by POGLUT1.
Phosphorylated by GSK3
- Protein Refseq
- NP_001186930.1; NP_077719.2
- Function
- Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination.
Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Affects the implementation of differentiation, proliferation and apoptotic programs.
Involved in bone remodeling and homeostasis.
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Related Diseases
Breast Cancer
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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| MOB-2555z | Mouse Anti-NOTCH2 Recombinant Antibody (clone 19B5) | ELISA, IHC | Mouse IgG1, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H67 | Anti-Human NOTCH2 Recombinant Antibody (TAB-H67) | FuncS, Block, ELISA | IgG2 - kappa |
| TAB-552MZ | Human Anti-NOTCH2 Recombinant Antibody (TAB-552MZ) | ELISA | Human IgG |
| TAB-552MZ-S(P) | Human Anti-NOTCH2 Recombinant Antibody; scFv Fragment (TAB-552MZ-S(P)) | ELISA | Human scFv |
| TAB-552MZ-F(E) | Human Anti-NOTCH2 Recombinant Antibody; Fab Fragment (TAB-552MZ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038-CN-S(P) | Human Anti-NOTCH2 Recombinant Antibody; scFv Fragment (HPAB-0038-CN-S(P)) | FC, ELISA | Human scFv |
| HPAB-0039-CN-S(P) | Human Anti-NOTCH2 Recombinant Antibody; scFv Fragment (HPAB-0039-CN-S(P)) | FC, ELISA | Human scFv |
| HPAB-0595-WJ-S(P) | Human Anti-NOTCH2 Recombinant Antibody scFv Fragment (HPAB-0595-WJ-S(P)) | ELISA, WB | Human scFv |
| HPAB-0596-WJ-S(P) | Human Anti-NOTCH2 Recombinant Antibody scFv Fragment (HPAB-0596-WJ-S(P)) | ELISA, WB | Human scFv |
| HPAB-0597-WJ-S(P) | Human Anti-NOTCH2 Recombinant Antibody scFv Fragment (HPAB-0597-WJ-S(P)) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038-CN-F(E) | Human Anti-NOTCH2 Recombinant Antibody; Fab Fragment (HPAB-0038-CN-F(E)) | FC, ELISA | Human Fab |
| HPAB-0039-CN-F(E) | Human Anti-NOTCH2 Recombinant Antibody; Fab Fragment (HPAB-0039-CN-F(E)) | FC, ELISA | Human Fab |
| HPAB-0595-WJ-F(E) | Human Anti-NOTCH2 Recombinant Antibody Fab Fragment (HPAB-0595-WJ-F(E)) | ELISA, WB | Human Fab |
| HPAB-0596-WJ-F(E) | Human Anti-NOTCH2 Recombinant Antibody Fab Fragment (HPAB-0596-WJ-F(E)) | ELISA, WB | Human Fab |
| HPAB-0597-WJ-F(E) | Human Anti-NOTCH2 Recombinant Antibody Fab Fragment (HPAB-0597-WJ-F(E)) | ELISA, WB | Human Fab |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| VS-0924-YC80 | Rabbit Anti-NOTCH2 Antibody (VS-0924-YC80) - Cancer Stem Cell Marker | IHC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY171 | CytoStream™ Rat Anti-NOTCH2 Recombinant Antibody (clone 16F11) | FC | Rat IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1507 | Anti-NOTCH2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4909 | Anti-Mouse NOTCH2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4908 | Anti-Human NOTCH2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC664 | Recombinant Anti-NOTCH2 Vesicular Antibody, EV Displayed (VS-0425-YC664) | ELISA, FC, Cell-uptake |
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