Human Anti-SLAMF7 (clone Elotuzumab) scFv-Fc Chimera
CAT#: VS-0425-FY183
The anti-SLAMF7 scFv-FC is a monoclonal antibody designed to target the SLAMF7 protein. The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to SLAMF7 with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of immunology and oncology.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61654/1269_D5_1_selected.jpg
Normal Tissue
Figure 2 Testis
Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_6_6.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (U-266/70)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000026751-SLAMF7
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Specifications
- Immunogen
- Human SLAMF7/CD319 as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human SLAMF7
- Species Reactivity
- Human
- Clone
- Elotuzumab
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer, inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- SLAM Family Member 7; Membrane Protein FOAP-12; CD2 Subset 1; Protein 19A; CRACC; CS1; Novel LY9 (Lymphocyte Antigen 9) Like Protein; CD2-Like Receptor Activating Cytotoxic Cells
- Gene ID
- 57823
- UniProt ID
- Q9NQ25
- Long Name
- SLAM Family Member 7
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn142, Asn148, Asn172, Asn176, Asn204, and Asn98
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites, 1 N-linked glycan (1 site)
- Protein Refseq
- XP_011508130.1; XP_011508131.1; XP_047282315.1; XP_054193911.1; XP_054193912.1
- Function
- Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family.
SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.
Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2.
Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway.
Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B.
Downstream signaling implicates PLCG1, PLCG2 and PI3K.
In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation.
However, in the absence of SH2D1B, inhibits NK cell function.
Acts also inhibitory in T-cells.
May play a role in lymphocyte adhesion.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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| HPAB-AP796-YC | Mouse Anti-SLAMF7 Recombinant Antibody (HPAB-AP796-YC) | ELISA, FC, IHC, Inhib | Mouse IgG1 |
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| HPAB-AP798-YC | Mouse Anti-SLAMF7 Recombinant Antibody (HPAB-AP798-YC) | ELISA, FC, IHC, Inhib | Mouse IgG2b |
| HPAB-AP799-YC | Human Anti-SLAMF7 Recombinant Antibody (HPAB-AP799-YC) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Humanized IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP796-YC-S(P) | Mouse Anti-SLAMF7 Recombinant Antibody; scFv Fragment (HPAB-AP796-YC-S(P)) | ELISA, FC, IHC, Inhib | Mouse scFv |
| HPAB-AP797-YC-S(P) | Mouse Anti-SLAMF7 Recombinant Antibody; scFv Fragment (HPAB-AP797-YC-S(P)) | ELISA, FC, IHC, Inhib | Mouse scFv |
| HPAB-AP798-YC-S(P) | Mouse Anti-SLAMF7 Recombinant Antibody; scFv Fragment (HPAB-AP798-YC-S(P)) | ELISA, FC, IHC, Inhib | Mouse scFv |
| HPAB-AP799-YC-S(P) | Human Anti-SLAMF7 Recombinant Antibody; scFv Fragment (HPAB-AP799-YC-S(P)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Human scFv |
| HPAB-AP800-YC-S(P) | Human Anti-SLAMF7 Recombinant Antibody; scFv Fragment (HPAB-AP800-YC-S(P)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
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| HPAB-AP796-YC-F(E) | Mouse Anti-SLAMF7 Recombinant Antibody; Fab Fragment (HPAB-AP796-YC-F(E)) | ELISA, FC, IHC, Inhib | Mouse Fab |
| HPAB-AP797-YC-F(E) | Mouse Anti-SLAMF7 Recombinant Antibody; Fab Fragment (HPAB-AP797-YC-F(E)) | ELISA, FC, IHC, Inhib | Mouse Fab |
| HPAB-AP798-YC-F(E) | Mouse Anti-SLAMF7 Recombinant Antibody; Fab Fragment (HPAB-AP798-YC-F(E)) | ELISA, FC, IHC, Inhib | Mouse Fab |
| HPAB-AP799-YC-F(E) | Human Anti-SLAMF7 Recombinant Antibody; Fab Fragment (HPAB-AP799-YC-F(E)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Humanized Fab |
| HPAB-AP800-YC-F(E) | Human Anti-SLAMF7 Recombinant Antibody; Fab Fragment (HPAB-AP800-YC-F(E)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Chimeric (Mouse/Human) Fab |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY6620 | Anti-SLAMF7 Immunohistochemistry Kit | IHC |
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