Human Anti-SLAMF7 (clone Elotuzumab) scFv-Fc Chimera (CAT#: VS-0425-FY183)

• Immunogen
• Human SLAMF7/CD319 as an immunogen.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human SLAMF7

• Species Reactivity
• Human

• Clone
• Elotuzumab

• Applications
• ELISA, Flow Cytometry

• Related Disease
• Cancer, inflammatory disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• SLAM Family Member 7; Membrane Protein FOAP-12; CD2 Subset 1; Protein 19A; CRACC; CS1; Novel LY9 (Lymphocyte Antigen 9) Like Protein; CD2-Like Receptor Activating Cytotoxic Cells

• Gene ID
• 57823

• UniProt ID
• Q9NQ25

• Long Name
• SLAM Family Member 7

• Cellular Localization
• Membrane

• Post Translation Modifications
• Glycosylation at Asn142, Asn148, Asn172, Asn176, Asn204, and Asn98
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 6 sites, 1 N-linked glycan (1 site)

• Protein Refseq
• XP_011508130.1; XP_011508131.1; XP_047282315.1; XP_054193911.1; XP_054193912.1

• Function
• Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family.
  SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.
  Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2.
  Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway.
  Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B.
  Downstream signaling implicates PLCG1, PLCG2 and PI3K.
  In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation.
  However, in the absence of SH2D1B, inhibits NK cell function.
  Acts also inhibitory in T-cells.
  May play a role in lymphocyte adhesion.

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