Human Anti-SLAMF7 (clone Elotuzumab) scFv-Fc Chimera

Name: Human Anti-SLAMF7 (clone Elotuzumab) scFv-Fc Chimera
SKU: VS-0425-FY183
Rating: 5 (1 reviews)

CAT#: VS-0425-FY183

The anti-SLAMF7 scFv-FC is a monoclonal antibody designed to target the SLAMF7 protein. The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to SLAMF7 with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of immunology and oncology.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line SK-MEL-30

Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61654/1269_D5_1_selected.jpg

Normal Tissue Figure 2 Testis

Spermatogonia cells Staining: Medium Intensity: Moderate

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_6_6.jpg

Normal Tissue Figure 3 Colon

Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_9_3.jpg

Normal Tissue Figure 4 Liver

Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_7_4.jpg

Normal Tissue Figure 5 Kidney

Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_8_5.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enriched (U-266/70)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000026751-SLAMF7

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Specifications

Immunogen
Human SLAMF7/CD319 as an immunogen.

Host Species
Human

Type
Human IgG1, scFv-Fc

Antibody Isotype
scFv-Fc

Specificity
Human SLAMF7

Species Reactivity
Human

Clone
Elotuzumab

Applications
ELISA, Flow Cytometry

Related Disease
Cancer, inflammatory disease

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
The optimal dilution concentration is determined by the experiment.

Target

Alternative Names
SLAM Family Member 7; Membrane Protein FOAP-12; CD2 Subset 1; Protein 19A; CRACC; CS1; Novel LY9 (Lymphocyte Antigen 9) Like Protein; CD2-Like Receptor Activating Cytotoxic Cells

Gene ID
57823

UniProt ID
Q9NQ25

Long Name
SLAM Family Member 7

Cellular Localization
Membrane

Post Translation Modifications
Glycosylation at Asn142, Asn148, Asn172, Asn176, Asn204, and Asn98
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites, 1 N-linked glycan (1 site)

Protein Refseq
XP_011508130.1; XP_011508131.1; XP_047282315.1; XP_054193911.1; XP_054193912.1

Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family.
SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.
Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2.
Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway.
Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B.
Downstream signaling implicates PLCG1, PLCG2 and PI3K.
In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation.
However, in the absence of SH2D1B, inhibits NK cell function.
Acts also inhibitory in T-cells.
May play a role in lymphocyte adhesion.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0425-FY183.pdf

MSDS

MSDS - VS-0425-FY183.pdf

COA

Certificate of Analysis Lookup

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