Afuco™ Anti-SLAMF7 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-743) (CAT#: AFC-TAB-743)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human SLAMF7/CD319. It is a humanized monoclonal antibody which is under phase III clinical investigation in relapsed multiple myeloma.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61654/1269_D5_1_selected.jpg
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61654/1269_D5_1_selected.jpg
Figure 2 Testis
(Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_6_6.jpg
(Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_6_6.jpg
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_9_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_9_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_7_4.jpg
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_7_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_8_5.jpg
Figure 6 RNA cell line category: Cell line enriched (U-266/70)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000026751-SLAMF7
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000026751-SLAMF7
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- FuncS, IF, Neut, ELISA, FC, IP
- Conjugate
- Unconjugated
- Generic Name
- Elotuzumab
- Related Disease
- Multiple myeloma (MM)
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- SLAMF7; SLAM family member 7; 19A; CD319; CRACC; CS1; protein 19A; CD2 subset 1; 19A24 protein; membrane protein FOAP-12; CD2-like receptor activating cytotoxic cells
- Gene ID
- 57823
- UniProt ID
- Q9NQ25
Related Resources
Please refer to Elotuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Elotuzumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "elotuzumab"
Anti-SLAMF7 Recombinant Antibody (Elotuzumab)Recombinant humanized antibody expressed in CHO binding to human SLAMF7/CD319. Elotuzumab is a humanized monoclonal antibody which is under phase III clinical investigation in relapsed multiple myeloma.
DrugMonitor™ Anti-Elotuzumab Antibody (VS-1224-YC413)Elotuzumab is a humanized IgG1 monoclonal antibody indicated for use with lenalidomide and dexamethasone in multiple myeloma treatment. The DrugMonitor™ Anti-Elotuzumab Antibody (VS-1224-YC413) is an anti-drug antibody (ADA) against Elotuzumab. This drug-based antibody is raised in mice immunized with the Elotuzumab. The anti-Elotuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Elotuzumab in samples.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1881z | Mouse Anti-SLAMF7 Recombinant Antibody (clone 4C10) | WB, IHC | Mouse IgG1 |
| VS3-WK1 | Rabbit Anti-SLAMF7 Recombinant Antibody (clone DM10) | ELISA, FC, IP, IF | Rabbit IgG |
| VS3-WK2 | Rabbit Anti-SLAMF7 Recombinant Antibody (clone DM11) | ELISA, FC, IP, IF | Rabbit IgG |
| VS3-FY274 | Recombinant Mouse Anti-SLAMF7 Antibody (clone 7A8D5) | ELISA, WB, IHC, FC | Mouse IgG1 |
| VS-0224-XY118 | Mouse Anti-SLAMF7 Recombinant Antibody (VS-0224-XY118), PE | FC | Mouse IgG2b |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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