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SLAMF7

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For Research Use Only. Not For Clinical Use.


Enables identical protein binding activity. Predicted to be involved in T cell activation and immune response. Predicted to act upstream of or within regulation of natural killer cell activation. Located in endoplasmic reticulum.
SLAMF7
Protein class

CD markers, FDA approved drug targets

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Plasma cells, monocytes, NK-cells, dendritic cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enriched (U-266/70)

Interaction

Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro); low affinity binding, the physiological relevance of the interaction is questioned. Interacts with SH2D1B; in NK cells (PubMed:16339536). Interacts (via ITSM phosphorylated on Tyr-302) with SH2D1B, PTPN6/SHP-1, PTPN11/SHP-2, INPP5D/SHIP1, CSK and FYN (By similarity).

Molecular function

Receptor

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