Recombinant Rabbit Anti-CCL5 Detection Antibody (clone R03-8P5) (CAT#: VS3-WK1755)

• Immunogen
• Recombinant human CCL5 protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human CCL5

• Species Reactivity
• Human

• Clone
• R03-8P5

• Applications
• ELISA

• Conjugate
• Unconjugated

• Clonality
• Monoclonal

• Purification
• Protein A affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Aggregation
• < 5%

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 0.01M PBS, pH 7.2

• Storage
• Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• C-C Motif Chemokine Ligand 5; SIS-Delta; Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5; Eosinophil Chemotactic Cytokine; Chemokine (C-C Motif) Ligand 5; T-Cell Specific Protein P288; Beta-Chemokine RANTES; D17S136E; TCP228; SCYA5

• Gene ID
• 6352

• UniProt ID
• P13501

• Long Name
• C-C Motif Chemokine Ligand 5

• Sequence Similarities
• Belongs to the intercrine beta (chemokine CC) family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
  N-terminal processed form RANTES(4-68) is produced by proteolytic cleavage by cathepsin CTSG.

• Protein Refseq
• NP_002976.2

• Function
• Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68).

Capture antibody

• VS3-WK1754
• Recombinant Rabbit Anti-CCL5 Capture Antibody (clone R06-8V9)

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2RD-A1517-YJ
• Sheep Anti-Rabbit IgG-heavy and light chain Secondary antibody