Recombinant Rabbit Anti-CCL5 Detection Antibody (clone R03-8P5) (CAT#: VS3-WK1755)
This antibody is a rabbit recombinant antibody against human CCL5. It was developed by immunization of rabbit with recombinant human CCL5 protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. R06-8V9 and R03-8P5 were identified as antibody pair for sandwich ELISA. As a detection antibody, the clone R03-8P5 can be used in ELISA analysis to identify human CCL5.
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Normal Tissue
RNA Expression
Figure 1 High expression in bone marrow.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_B_4_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_B_4_4_val_selected.jpg
Figure 2 Low expression in skin 1.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_B_7_1_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_B_7_1_val_selected.jpg
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_A_8_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_A_8_3.jpg
Figure 4 Kidney
(Cells in tubules Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_A_8_5.jpg
(Cells in tubules Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_A_8_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000271503-CCL5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000271503-CCL5
Figure 1 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000271503-CCL5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000271503-CCL5
Specifications
- Immunogen
- Recombinant human CCL5 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CCL5
- Species Reactivity
- Human
- Clone
- R03-8P5
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- C-C Motif Chemokine Ligand 5; SIS-Delta; Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5; Eosinophil Chemotactic Cytokine; Chemokine (C-C Motif) Ligand 5; T-Cell Specific Protein P288; Beta-Chemokine RANTES; D17S136E; TCP228; SCYA5
- Gene ID
- 6352
- UniProt ID
- P13501
- Long Name
- C-C Motif Chemokine Ligand 5
- Sequence Similarities
- Belongs to the intercrine beta (chemokine CC) family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
N-terminal processed form RANTES(4-68) is produced by proteolytic cleavage by cathepsin CTSG.
- Protein Refseq
- NP_002976.2
- Function
- Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1352z | Mouse Anti-CCL5 Recombinant Antibody (clone 22C12) | ELISA, IHC, WB | Mouse IgG1 |
| HPAB-0378LY | Human Anti-CCL5 Recombinant Antibody (clone 1E4) | ELISA, Inhib | Human IgG1 |
| HPAB-0379LY | Human Anti-CCL5 Recombinant Antibody (clone C8) | ELISA, Inhib | Human IgG1 |
| HPAB-0380LY | Human Anti-CCL5 Recombinant Antibody (clone 1D9) | ELISA, Inhib, FC, IF | Human IgG1 |
| HPAB-0381LY | Human Anti-CCL5 Recombinant Antibody (clone D9) | ELISA, Inhib | Human IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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