Recombinant Anti-CD46 Vesicular Antibody, EV Displayed (VS-0425-YC188) (CAT#: VS-0425-YC188)
The Recombinant Anti-CD46 Vesicular Antibody, EV Displayed (VS-0425-YC188) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CD46-expressed cells or tissues. The CD46 is a protein involved in complement and coagulation cascades, related to diseases such as Atypical Hemolytic Uremic Syndrome. It has receptor and enzyme inhibitor activities.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/ihc_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/211_E5_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/211_E5_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/209_E5_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/209_E5_1_blue_red_green.jpg
Figure 5 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16903/38899_A_9_3.jpg
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16903/38899_A_9_3.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CD46
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- CD46 molecule
- Biological Process
- Complement pathway, Fertilization, Host-virus interaction, Immunity, Innate immunity
- Molecular Function
- Host cell receptor for virus entry, Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- CD46 (CD46 Molecule) is a Protein Coding gene. Diseases associated with CD46 include Hemolytic Uremic Syndrome, Atypical 2 and Measles. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include receptor activity and enzyme inhibitor activity. An important paralog of this gene is C4BPA.
- Alternative Names
- MCP, MGC26544, MIC10, TLX, TRA2.10
- Gene ID
- 4179
- UniProt ID
- P15529
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CD46"
Select a product category from the dropdown menu below to view related products.
Please select product type
Human Antibody Products
Mouse Antibody Products
Humanized Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
Antibody Magnetic Beads
ScFv-Fc Chimera Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0288CL-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-0288CL-S(P)) | RIA, ELISA, FC | Human scFv |
| TAB-0289CL-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-0289CL-S(P)) | RIA, ELISA, FC | Human scFv |
| TAB-0290CL-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-0290CL-S(P)) | RIA, ELISA, FC | Human scFv |
| TAB-0291CL-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-0291CL-S(P)) | RIA, ELISA, FC | Human scFv |
| TAB-0292CL-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-0292CL-S(P)) | RIA, ELISA, FC | Human scFv |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0425-YC188. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, WB
Application: WB, ELISA, IF
Application: WB, ELISA, IF, FuncS, Apop, BA
Application: ELISA, FC
Application: FC
Application: ELISA, Activ, Block
Application: ELISA, Vaccine, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
