Recombinant Anti-CD46 Vesicular Antibody, EV Displayed (VS-0425-YC188)
CAT#: VS-0425-YC188
The Recombinant Anti-CD46 Vesicular Antibody, EV Displayed (VS-0425-YC188) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CD46-expressed cells or tissues. The CD46 is a protein involved in complement and coagulation cascades, related to diseases such as Atypical Hemolytic Uremic Syndrome. It has receptor and enzyme inhibitor activities.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/211_E5_1_blue_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/209_E5_1_blue_red_green.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16903/38899_A_9_3.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CD46
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- CD46 molecule
- Biological Process
- Complement pathway, Fertilization, Host-virus interaction, Immunity, Innate immunity
- Molecular Function
- Host cell receptor for virus entry, Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- CD46 (CD46 Molecule) is a Protein Coding gene. Diseases associated with CD46 include Hemolytic Uremic Syndrome, Atypical 2 and Measles. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include receptor activity and enzyme inhibitor activity. An important paralog of this gene is C4BPA.
- Alternative Names
- MCP, MGC26544, MIC10, TLX, TRA2.10
- Gene ID
- 4179
- UniProt ID
- P15529
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Datasheet
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COA
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See other products for "CD46"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0288CL-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-0288CL-S(P)) | RIA, ELISA, FC | Human scFv |
| TAB-0289CL-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-0289CL-S(P)) | RIA, ELISA, FC | Human scFv |
| TAB-0290CL-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-0290CL-S(P)) | RIA, ELISA, FC | Human scFv |
| TAB-0291CL-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-0291CL-S(P)) | RIA, ELISA, FC | Human scFv |
| TAB-0292CL-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-0292CL-S(P)) | RIA, ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-268LC | Mouse Anti-CD46 Recombinant Antibody (TAB-268LC) | Cyt, FuncS | Mouse IgG |
| TAB-269LC | Mouse Anti-CD46 Recombinant Antibody (TAB-269LC) | Cyt, FuncS | Mouse IgG |
| TAB-268LC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-268LC-F(E)) | FC, ELISA | Mouse Fab |
| TAB-269LC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-269LC-F(E)) | FC, ELISA | Mouse Fab |
| TAB-272LC-F(E) | Anti-Human CD46 Recombinant Antibody Fab Fragment (mPA7) | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-270LC | Human Anti-CD46 Recombinant Antibody (TAB-270LC) | Cyt, FuncS | Humanized IgG1, κ |
| TAB-271LC | Human Anti-CD46 Recombinant Antibody (TAB-271LC) | Cyt, FuncS | Humanized IgG1, κ |
| TAB-270LC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-270LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-270LC-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-270LC-F(E)) | FC, ELISA | Humanized Fab |
| TAB-271LC-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-271LC-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-385CQ | Mouse Anti-CD46 Recombinant Antibody (NEUT-385CQ) | FC, Block, IF, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0564 | Hi-Affi™ Rabbit Anti-CD46 Recombinant Antibody (clone DS564AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0524-CN-S(P)) | WB, ELISA, FC, IHC, IP | Human scFv |
| HPAB-0525-CN-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0525-CN-S(P)) | WB, ELISA, FC, IHC, IP | Human scFv |
| HPAB-0366-YC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0366-YC-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0368-YC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0368-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0524-CN-F(E)) | WB, ELISA, FC, IHC, IP | Human Fab |
| HPAB-0525-CN-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0525-CN-F(E)) | WB, ELISA, FC, IHC, IP | Human Fab |
| HPAB-0367-YC-F(E) | Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0368-YC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0368-YC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0723-WK258 | Rabbit Anti-CD46 Recombinant Antibody (VS-0723-WK258) | ELISA, FC | Rabbit IgG |
| VS3-XY3298 | Rabbit Anti-CD46 Recombinant Antibody (clone R06-3I6) | WB, IHC-P, ICC, IF | Rabbit IgG |
| VS7-HM600 | Mouse Anti-CD46 Recombinant Antibody (clone 1A5A5) | IHC, FCM | Mouse IgG1 |
| VS7-HM601 | Mouse Anti-CD46 Recombinant Antibody (clone 5A8C11) | WB, ICC, FCM | Mouse IgG1 |
| VS13-YC166 | Rabbit Anti-CD46 Recombinant Antibody (VS13-YC166) | WB, ICC, IF, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY54 | AbPlus™ Anti-CD46 Magnetic Beads (VS-0424-XY54) | IP, Protein Purification | |
| VS-0724-YC422 | AbPlus™ Anti-CD46 Magnetic Beads (VS-0724-YC422) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY113 | Mouse Anti-CD46 (clone mPA7) scFv-Fc Chimera | Inhib, WB | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY367 | Anti-CD46 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1189 | Anti-Rat CD46 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1190 | Anti-Mouse CD46 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1188 | Anti-Human CD46 Immunohistochemistry Kit | IHC |
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