Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122) (CAT#: HPAB-0367-YC)
The product is a new CD46 modulator that effectively targets cancer stem cells and could potentially be used to treat patients with various types of cancers. The data indicates that the antibody is a broad-spectrum CD46 antibody, as it binds to CD46 exons 1-6, CD46D-His, CD46F-His, and CD46J-His. The use of anti-CD46 antibody may lead to a decrease in the frequency of tumor initiating cells, making it a promising option for immunotherapeutic treatment of malignancies.
Specific Inquiry
ELISA
Figure IIlustrate ELISA data shows binding of anti-CD46 antibodies SC1.N122 and SC1.N29 to various regions of CD46.
Specifications
- Immunogen
- Both the recombinant fusion protein comprising the extracellular portion of CD46-D-His and two synthetic peptides derived from the CD46 protein sequence and located within the exon-exon junctions of exons 6-8 and 6-9.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human CD46
- Species Reactivity
- Human
- Clone
- SC1.N122
- Applications
- ELISA, FC
- Related Disease
- Hyperproliferative disorder
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry.
Target
- Alternative Names
- CD46 Molecule, Complement Regulatory Protein; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; MIC10; MCP; TLX; Trophoblast-Lymphocyte Cross-Reactive Antigen; Complement Membrane Cofactor Protein; Trophoblast Leucocyte Common Antigen; Measles Virus Receptor; CD46 Antigen; TRA2.10; AHUS2
- Gene ID
- 4179
- UniProt ID
- P15529
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone SC1.N122"
See other products for "CD46"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1132z | Mouse Anti-CD46 Recombinant Antibody (clone 12A2) | WB, ELISA, FC, IF, IHC, IP, FuncS | Mouse IgG1, κ |
| MRO-0308-CN | Rabbit Anti-CD46 Recombinant Antibody (clone JB25-49) | WB, IF, IHC | Rabbit IgG |
| MOR-0022-FY | Mouse Anti-CD46 Recombinant Antibody (clone M177) | FC, FuncS, IA, IP, WB | Mouse IgG1 |
| ZG-0134U | Rabbit Anti-CD46 Recombinant Antibody (clone 7D12) | ELISA, WB, IHC | Rabbit IgG |
| VS-0723-WK258 | Rabbit Anti-CD46 Recombinant Antibody (VS-0723-WK258) | ELISA, FC | Rabbit IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0288CL-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-0288CL-F(E)) | RIA, ELISA, FC | Human Fab |
| TAB-0289CL-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-0289CL-F(E)) | RIA, ELISA, FC | Human Fab |
| TAB-0290CL-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-0290CL-F(E)) | RIA, ELISA, FC | Human Fab |
| TAB-0291CL-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-0291CL-F(E)) | RIA, ELISA, FC | Human Fab |
| TAB-267LC-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-267LC-F(E)) | IHC, ELISA | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-268LC | Mouse Anti-CD46 Recombinant Antibody (TAB-268LC) | Cyt, FuncS | Mouse IgG |
| TAB-269LC | Mouse Anti-CD46 Recombinant Antibody (TAB-269LC) | Cyt, FuncS | Mouse IgG |
| TAB-272LC | Anti-Human CD46 Recombinant Antibody (mPA7) | FuncS, Inhib, WB | |
| TAB-268LC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-268LC-S(P)) | FC, ELISA | Mouse scFv |
| TAB-269LC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-269LC-S(P)) | FC, ELISA | Mouse scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-270LC | Human Anti-CD46 Recombinant Antibody (TAB-270LC) | Cyt, FuncS | Humanized IgG1, κ |
| TAB-271LC | Human Anti-CD46 Recombinant Antibody (TAB-271LC) | Cyt, FuncS | Humanized IgG1, κ |
| TAB-270LC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-270LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-271LC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-271LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-270LC-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-270LC-F(E)) | FC, ELISA | Humanized Fab |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-385CQ | Mouse Anti-CD46 Recombinant Antibody (clone TRA-2-10) | FC, Block, IF, IP | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0564 | Hi-Affi™ Rabbit Anti-CD46 Recombinant Antibody (clone DS564AB) | ICC, IHC-P, WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0524-CN-S(P)) | WB, ELISA, FC, IHC, IP | Human scFv |
| HPAB-0525-CN-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0525-CN-S(P)) | WB, ELISA, FC, IHC, IP | Human scFv |
| HPAB-0366-YC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0366-YC-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0368-YC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0368-YC-S(P)) | ELISA, FC | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0524-CN-F(E)) | WB, ELISA, FC, IHC, IP | Human Fab |
| HPAB-0525-CN-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0525-CN-F(E)) | WB, ELISA, FC, IHC, IP | Human Fab |
| HPAB-0367-YC-F(E) | Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0368-YC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0368-YC-F(E)) | ELISA, FC | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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