Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122)
CAT#: HPAB-0367-YC
The product is a new CD46 modulator that effectively targets cancer stem cells and could potentially be used to treat patients with various types of cancers. The data indicates that the antibody is a broad-spectrum CD46 antibody, as it binds to CD46 exons 1-6, CD46D-His, CD46F-His, and CD46J-His. The use of anti-CD46 antibody may lead to a decrease in the frequency of tumor initiating cells, making it a promising option for immunotherapeutic treatment of malignancies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
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Specifications
- Immunogen
- Both the recombinant fusion protein comprising the extracellular portion of CD46-D-His and two synthetic peptides derived from the CD46 protein sequence and located within the exon-exon junctions of exons 6-8 and 6-9.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human CD46
- Species Reactivity
- Human
- Clone
- SC1.N122
- Applications
- ELISA, FC
- Related Disease
- Hyperproliferative disorder
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry.
Target
- Alternative Names
- CD46 Molecule, Complement Regulatory Protein; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; MIC10; MCP; TLX; Trophoblast-Lymphocyte Cross-Reactive Antigen; Complement Membrane Cofactor Protein; Trophoblast Leucocyte Common Antigen; Measles Virus Receptor; CD46 Antigen; TRA2.10; AHUS2
- Gene ID
- 4179
- UniProt ID
- P15529
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone SC1.N122"
- CAT
- Product Name
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|---|---|---|---|
| TAB-0288CL | Human Anti-CD46 Recombinant Antibody (TAB-0288CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0289CL | Human Anti-CD46 Recombinant Antibody (TAB-0289CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0290CL | Human Anti-CD46 Recombinant Antibody (TAB-0290CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0291CL | Human Anti-CD46 Recombinant Antibody (TAB-0291CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0292CL | Human Anti-CD46 Recombinant Antibody (TAB-0292CL) | RIA, ELISA, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-268LC | Mouse Anti-CD46 Recombinant Antibody (TAB-268LC) | Cyt, FuncS | Mouse IgG |
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| CAT | Product Name | Application | Type |
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| TAB-270LC | Human Anti-CD46 Recombinant Antibody (TAB-270LC) | Cyt, FuncS | Humanized IgG1, κ |
| TAB-271LC | Human Anti-CD46 Recombinant Antibody (TAB-271LC) | Cyt, FuncS | Humanized IgG1, κ |
| TAB-270LC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-270LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-271LC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-271LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-270LC-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-270LC-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-385CQ | Mouse Anti-CD46 Recombinant Antibody (NEUT-385CQ) | FC, Block, IF, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0524-CN-S(P)) | WB, ELISA, FC, IHC, IP | Human scFv |
| HPAB-0525-CN-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0525-CN-S(P)) | WB, ELISA, FC, IHC, IP | Human scFv |
| HPAB-0366-YC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0366-YC-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0368-YC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0368-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0524-CN-F(E)) | WB, ELISA, FC, IHC, IP | Human Fab |
| HPAB-0525-CN-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0525-CN-F(E)) | WB, ELISA, FC, IHC, IP | Human Fab |
| HPAB-0367-YC-F(E) | Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0368-YC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0368-YC-F(E)) | ELISA, FC | Mouse Fab |
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