Mouse Anti-CD46 (clone mPA7) scFv-Fc Chimera
CAT#: VS-0325-FY113
The anti-CD46 scFv-Fc antibody is designed to bind specifically to CD46, a regulator of complement activation expressed on nearly all human cells. It is valuable for investigating the role of CD46 in immune regulation, viral infections, and autoimmune diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/211_E5_1_blue_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/209_E5_1_blue_red_green.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16903/38899_A_9_3.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
❮
❯
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human CD46
- Species Reactivity
- Human
- Clone
- mPA7
- Applications
- Inhibition, Western Blot
- Related Disease
- Autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Inhibition: mPA7 inhibited LN-CaP cell growth by up to 90% at concentrations ranging from 1.5 µg/mL to 50 µg/mL.
Western Blot: 5 µg/mL
Target
- Alternative Names
- CD46 Molecule; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Molecule, Complement Regulatory Protein; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; MIC10; MCP; TLX
- Gene ID
- 4179
- UniProt ID
- P15529
- Long Name
- CD46 Molecule
- Cellular Localization
- Cytoplasmic vesicle, Membrane
- Post Translation Modifications
- N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding.
- Protein Refseq
- XP_047276844.1; XP_011507865.1
- Function
- Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0325-FY113. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
See other products for "Clone mPA7"
- CAT
- Product Name
See other products for "CD46"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1132z | Mouse Anti-CD46 Recombinant Antibody (clone 12A2) | WB, ELISA, FC, IF, IHC, IP, FuncS | Mouse IgG1, κ |
| HPAB-0524-CN | Human Anti-CD46 Recombinant Antibody (HPAB-0524-CN) | WB, ELISA, FC, IHC, IP | Human IgG1 |
| HPAB-0525-CN | Human Anti-CD46 Recombinant Antibody (HPAB-0525-CN) | WB, ELISA, FC, IHC, IP | Human IgG1 |
| HPAB-0367-YC | Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122) | ELISA, FC | Mouse IgG |
| ZG-0134U | Rabbit Anti-CD46 Recombinant Antibody (clone 7D12) | ELISA, WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0288CL-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-0288CL-F(E)) | RIA, ELISA, FC | Human Fab |
| TAB-0289CL-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-0289CL-F(E)) | RIA, ELISA, FC | Human Fab |
| TAB-0290CL-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-0290CL-F(E)) | RIA, ELISA, FC | Human Fab |
| TAB-0291CL-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-0291CL-F(E)) | RIA, ELISA, FC | Human Fab |
| TAB-267LC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-267LC-S(P)) | IHC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-270LC | Human Anti-CD46 Recombinant Antibody (TAB-270LC) | Cyt, FuncS | Humanized IgG1, κ |
| TAB-270LC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-270LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-271LC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-271LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-270LC-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-270LC-F(E)) | FC, ELISA | Humanized Fab |
| TAB-271LC-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-271LC-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-268LC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-268LC-S(P)) | FC, ELISA | Mouse scFv |
| TAB-269LC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-269LC-S(P)) | FC, ELISA | Mouse scFv |
| TAB-272LC-S(P) | Anti-Human CD46 Recombinant Antibody scFv Fragment (mPA7) | IHC | |
| TAB-268LC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-268LC-F(E)) | FC, ELISA | Mouse Fab |
| TAB-269LC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-269LC-F(E)) | FC, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-385CQ | Mouse Anti-CD46 Recombinant Antibody (NEUT-385CQ) | FC, Block, IF, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0564 | Hi-Affi™ Rabbit Anti-CD46 Recombinant Antibody (clone DS564AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0524-CN-S(P)) | WB, ELISA, FC, IHC, IP | Human scFv |
| HPAB-0525-CN-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0525-CN-S(P)) | WB, ELISA, FC, IHC, IP | Human scFv |
| HPAB-0366-YC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0366-YC-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0368-YC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0368-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0524-CN-F(E)) | WB, ELISA, FC, IHC, IP | Human Fab |
| HPAB-0525-CN-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0525-CN-F(E)) | WB, ELISA, FC, IHC, IP | Human Fab |
| HPAB-0367-YC-F(E) | Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0368-YC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0368-YC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY54 | AbPlus™ Anti-CD46 Magnetic Beads (VS-0424-XY54) | IP, Protein Purification | |
| VS-0724-YC422 | AbPlus™ Anti-CD46 Magnetic Beads (VS-0724-YC422) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY367 | Anti-CD46 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1189 | Anti-Rat CD46 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1190 | Anti-Mouse CD46 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1188 | Anti-Human CD46 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC188 | Recombinant Anti-CD46 Vesicular Antibody, EV Displayed (VS-0425-YC188) | ELISA, FC, Cell-uptake |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application:
Application: Neut, FC
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, WB, Microarray, Block
-3.jpg)
Application: ELISA, WB
-2.png)
Application: ELISA, WB
Application: ELISA, Inhib, FuncS
Application: ELISA, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
