Recombinant Anti-CXCR2 Vesicular Antibody, EV Displayed (VS-0425-YC259)
CAT#: VS-0425-YC259
The Recombinant Anti-CXCR2 Vesicular Antibody, EV Displayed (VS-0425-YC259) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CXCR2-expressed cells or tissues. The CXCR2 is a chemokine receptor involved in migration and immune system pathways, associated with neutropenia conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line THP-1
Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane, microtubules & mitotic spindle.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31999/1855_E6_15_cr5ad88637398d2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line THP-1
Immunofluorescent staining of human cell line THP-1 shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/1855_F6_25_cr5ad88701bb05e_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/139603_B_9_5.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/139603_A_8_8.jpg
Normal Tissue
Figure 5 High expression in spleen
Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/139603_B_9_4.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (BEWO, HL-60, HMC-1, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000180871-CXCR2
❮
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CXCR2
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- C-X-C motif chemokine receptor 2
- Biological Process
- Chemotaxis
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Plasma membrane, Nucleoplasm, Microtubules, Mitotic spindle
- Introduction
- CXCR2 (C-X-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CXCR2 include Autosomal Recessive Severe Congenital Neutropenia Due To Cxcr2 Deficiency and Neutrophil Migration. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CXCR1.
- Alternative Names
- CD182, CMKAR2, IL8RB
- Gene ID
- 3579
- UniProt ID
- P25025
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Datasheet
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COA
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