Anti-CXCR2 Recombinant Antibody Products

Loading...

Anti-CXCR2 Products

+ Filter

Loading...

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Creative Biolabs is a trusted name in chronic inflammation and oncology research, offering leading-edge anti-CXCR2 recombinant antibodies. CXCR2, as the second receptor for IL-8, a key driver of neutrophil trafficking, has become a major therapeutic target for many inflammatory and pulmonary disorders. Our top-quality antibodies are critical for dissecting its involvement in neutrophil accumulation in the tissue, tumor angiogenesis, and disease pathology.

CXCR2: The Key Receptor for Neutrophil Trafficking

CXCR2, also known as C-X-C Motif Chemokine Receptor 2 or IL-8 Receptor Beta, is a G protein-coupled receptor (GPCR) that is abundantly expressed on neutrophils and endothelial progenitor cells. It binds and responds to multiple chemokines, including CXCL8 (IL-8), CXCL1, and CXCL2. CXCR2 signaling is the dominant pathway that mediates sustained extravasation and accumulation of neutrophils at sites of chronic inflammation (e.g., COPD, cystic fibrosis) as well as in the tumor microenvironment (TME). In the TME, CXCR2-dependent neutrophil accumulation also facilitates tumor growth through angiogenesis. Blocking CXCR2 signaling is one of the most promising therapeutic approaches to mitigate pathogenic neutrophil accumulation in chronic diseases.

Alternative Names

CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor; beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B

Background

CXCR2 (C-X-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CXCR2 include Autosomal Recessive Severe Congenital Neutropenia Due To Cxcr2 Deficiency and Neutrophil Migration. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CXCR1.

Anti-CXCR2 rAb Products

Our anti-CXCR2 recombinant antibodies have been engineered to ensure optimal specificity and potent functional activity. We perform extensive validation of each batch to ensure robust and specific detection of CXCR2 on the surface of primary human neutrophils. Our rAbs are optimized for use in flow cytometry, IHC on inflamed tissues, and functional blocking of chemotaxis and are among the premier tools for immunology research and drug discovery.

Table 1. Featured anti-CXCR2 recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

M**ra
Human Anti-CXCR2 Recombinant Antibody (clone HY29)

We are investigating tumor angiogenesis, and this antibody has been great for us in visualizing CXCR2-positive endothelial progenitor cells in tumor stroma. An excellent and very reliable product.

29/Feb/2023

rAb Production

Creative Biolabs is dedicated to helping you move fast in drug discovery, which is why we leverage the most advanced production technologies available. Our anti-CXCR2 recombinant antibodies are produced to recognize the native conformation of the extracellular domains of this receptor, ensuring high functional activity.

Featured Anti-CXCR2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CXCR2 recombinant antibody production.

Fig.2 Gram-scale anti-CXCR2 recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to offering the research community the most flexible and innovative tools possible. We offer our anti-CXCR2 recombinant antibodies in a variety of customizable formats, including functional blocking clones, conjugates, and more, so researchers around the world can study this important receptor.

Fig.3 Full-length anti-CXCR2 recombinant antibody production and modalities.

CXCR2-Targeted Drug Information

Table 2. Public drug targeting CXCR2.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Discover the high quality of Creative Biolabs' anti-CXCR2 recombinant antibodies. Our portfolio is built on high specificity and functional validation, making our antibodies the ideal tools for exploring neutrophil-driven pathologies. Rely on our expertise to support your critical work. Speak with our experts today.