Human Anti-CXCR2 Recombinant Antibody (clone HY29) (CAT#: HPAB-0306-YC)
An isolated antibody (HY29) specifically binds to CXC chemokine receptor-2 (CXCR2), wherein the binding molecule can inhibit binding to interleukin 8 (IL-8). Mapping of the N terminus using linear peptides and alanine scanning of CLIPS peptides derived from the N terminus and ECL3 showed that the minimal epitope for the antibody binding was centered around the 31 PFLLD 35 with the second leucine and the aspartic acid key to the binding interaction.
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Custom Production
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FC
Figure 1 Binding of HY29 to human neutrophils and neutrophils isolated from cynomolgus monkeys.
ELISA
Figure 2 Example of competition of antibodies with DyLight-649 labelled HY29 binding to HEK human CXCR2 cells.
Inhib
Figure 3 HY29 Inhibition of Gro-cx and IL-8 driven human neutrophil chemotaxis.
FuncS
Figure 4 Tumor growth inhibition in syngeneic mouse tumor models in human CXCR2 transgenic mice.
FuncS
Figure 5 Tumor growth inhibition in KRAS mutant lung cancer patient derived xenograft tumor model.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG1
- Specificity
- Human CXCR2
- Species Reactivity
- Human, Monkey, Mouse
- Clone
- HY29
- Applications
- ELISA, FC, FuncS
- Related Disease
- Cancer, Inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry, Functional Assay.
Target
- Alternative Names
- CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor; beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B
- Gene ID
- 3579
- UniProt ID
- P25025
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Single Domain Antibody Products
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-050 | Recombinant Anti-Human CXCR2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-002MZ-VHH | Anti-Human CXCR2 Recombinant Antibody (TAB-002MZ-VHH) | FC, Inhib | Single domain antibody |
| TAB-004MZ-VHH | Anti-Human CXCR2 Recombinant Antibody (TAB-004MZ-VHH) | ELISA, IHC, FuncS, SPR | Single domain antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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