This antibody is capable of binding to and modulating signaling from CXC chemokine receptor-2 (CXCR2) which may be used in treatment of cancers and inflammatory diseases.
Figure 1 Binding of HY29 to human neutrophils and neutrophils isolated from cynomolgus monkeys.
Figure 2 Example of IL-8 dose response curves in the presence of increasing concentrations of HY29 Antibody.
Figure 3 HY29 Inhibition of Gro-cx and IL-8 driven human neutrophil chemotaxis
Figure 4 Tumor growth inhibition in syngeneic mouse tumor models in human CXCR2 transgenic mice.
Figure 5 Tumor growth inhibition in KRAS mutant lung cancer patient derived xenograft tumor model.
Figure 6 HY29 inhibition of pancreatic cancer cell growth in 3D.
The figure shows 14 day viability of four pancreatic tumor cell l ines in 3D matrigel overlay culture. Images were captured under phase contrast microscopy. Upper panel shows phase contrast micrograph, lower panel shows viability (left hand panel ) and 3D structure number ( right panel ). Significance was tested by one way ANOVA, error bars represent standard deviation.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Select a product category from the dropdown menu below to view related products.
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NABG-050 | Recombinant Anti-Human CXCR2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
TAB-002MZ-VHH | Anti-Human CXCR2 Recombinant Antibody (TAB-002MZ-VHH) | FC, Inhib | Single domain antibody |
TAB-004MZ-VHH | Anti-Human CXCR2 Recombinant Antibody (TAB-004MZ-VHH) | ELISA, IHC, FuncS, SPR | Single domain antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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