Anti-Human CXCR2 Recombinant Antibody (HY29) (CAT#: TAB-117MZ)

This antibody is capable of binding to and modulating signaling from CXC chemokine receptor-2 (CXCR2) which may be used in treatment of cancers and inflammatory diseases.

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FC

Figure 1 Binding of HY29 to human neutrophils and neutrophils isolated from cynomolgus monkeys.

Figure 1 Binding of HY29 to human neutrophils and neutrophils isolated from cynomolgus monkeys.

FuncS

Figure 2 Example of IL-8 dose response curves in the presence of increasing concentrations of HY29 Antibody.

Figure 2 Example of IL-8 dose response curves in the presence of increasing concentrations of HY29 Antibody.

Inhib

Figure 3 HY29 Inhibition of Gro-cx and IL-8 driven human neutrophil chemotaxis

Figure 3 HY29 Inhibition of Gro-cx and IL-8 driven human neutrophil chemotaxis

FuncS

Figure 4 Tumor growth inhibition in syngeneic mouse tumor models in human CXCR2 transgenic mice.

Figure 4 Tumor growth inhibition in syngeneic mouse tumor models in human CXCR2 transgenic mice.

FuncS

Figure 5 Tumor growth inhibition in KRAS mutant lung cancer patient derived xenograft tumor model.

Figure 5 Tumor growth inhibition in KRAS mutant lung cancer patient derived xenograft tumor model.

FuncS

Figure 6 HY29 inhibition of pancreatic cancer cell growth in 3D.

Figure 6 HY29 inhibition of pancreatic cancer cell growth in 3D.

The figure shows 14 day viability of four pancreatic tumor cell l ines in 3D matrigel overlay culture. Images were captured under phase contrast microscopy. Upper panel shows phase contrast micrograph, lower panel shows viability (left hand panel ) and 3D structure number ( right panel ). Significance was tested by one way ANOVA, error bars represent standard deviation.


Specifications

  • Host Species
  • Human
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Clone
  • HY29
  • Applications
  • FC, FuncS, Inhib
  • Related Disease
  • Lymphoma, colon cancer, lung cancer, melanoma, or pancreatic cancer

Applications

  • Application Notes
  • This antibody has been reported for use in Flow Cytotoxicityometry, Functional Assay, Inhibition.

Target

  • Alternative Names
  • CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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CAT Product Name Application Type
NABG-050 Recombinant Anti-Human CXCR2 VHH Single Domain Antibody ELISA, IHC, FC, FuncS Llama VHH
TAB-002MZ-VHH Anti-Human CXCR2 Recombinant Antibody (TAB-002MZ-VHH) FC, Inhib Single domain antibody
TAB-004MZ-VHH Anti-Human CXCR2 Recombinant Antibody (TAB-004MZ-VHH) ELISA, IHC, FuncS, SPR Single domain antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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