Anti-Human CXCR2 Therapeutic Antibody (HY29) (CAT#: TAB-117MZ)

This antibody is capable of binding to and modulating signaling from CXC chemokine receptor-2 (CXCR2) which may be used in treatment of cancers and inflammatory diseases.

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FC

Figure 1 Binding of HY29 to human neutrophils and neutrophils isolated from cynomolgus monkeys.

FuncS

Figure 2 Example of IL-8 dose response curves in the presence of increasing concentrations of HY29 Antibody.

Inhib

Figure 3 HY29 Inhibition of Gro-cx and IL-8 driven human neutrophil chemotaxis

FuncS

Figure 4 Tumor growth inhibition in syngeneic mouse tumor models in human CXCR2 transgenic mice.

FuncS

Figure 5 Tumor growth inhibition in KRAS mutant lung cancer patient derived xenograft tumor model.

FuncS

Figure 6 HY29 inhibition of pancreatic cancer cell growth in 3D.

The figure shows 14 day viability of four pancreatic tumor cell l ines in 3D matrigel overlay culture. Images were captured under phase contrast microscopy. Upper panel shows phase contrast micrograph, lower panel shows viability (left hand panel ) and 3D structure number ( right panel ). Significance was tested by one way ANOVA, error bars represent standard deviation.


Specifications

  • Host Species
  • Human
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Clone
  • HY29
  • Applications
  • FC, FuncS, Inhib
  • Related Disease
  • Lymphoma, colon cancer, lung cancer, melanoma, or pancreatic cancer

Applications

  • Application Notes
  • This antibody has been reported for use in Flow Cytotoxicityometry, Functional Assay, Inhibition.

Target

  • Alternative Names
  • CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

See other products for "CXCR2"

See other products for "Clone HY29"


For research use only. Not intended for any clinical use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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