Anti-Human CXCR2 Recombinant Antibody (HY29) (CAT#: TAB-117MZ)
This antibody is capable of binding to and modulating signaling from CXC chemokine receptor-2 (CXCR2) which may be used in treatment of cancers and inflammatory diseases.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
FC
Figure 1 Binding of HY29 to human neutrophils and neutrophils isolated from cynomolgus monkeys.
FuncS
Figure 2 Example of IL-8 dose response curves in the presence of increasing concentrations of HY29 Antibody.
Inhib
Figure 3 HY29 Inhibition of Gro-cx and IL-8 driven human neutrophil chemotaxis
FuncS
Figure 4 Tumor growth inhibition in syngeneic mouse tumor models in human CXCR2 transgenic mice.
FuncS
Figure 5 Tumor growth inhibition in KRAS mutant lung cancer patient derived xenograft tumor model.
FuncS
Figure 6 HY29 inhibition of pancreatic cancer cell growth in 3D.
The figure shows 14 day viability of four pancreatic tumor cell l ines in 3D matrigel overlay culture. Images were captured under phase contrast microscopy. Upper panel shows phase contrast micrograph, lower panel shows viability (left hand panel ) and 3D structure number ( right panel ). Significance was tested by one way ANOVA, error bars represent standard deviation.
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- HY29
- Applications
- FC, FuncS, Inhib
- Related Disease
- Lymphoma, colon cancer, lung cancer, melanoma, or pancreatic cancer
Applications
- Application Notes
- This antibody has been reported for use in Flow Cytotoxicityometry, Functional Assay, Inhibition.
Target
- Alternative Names
- CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B
- Gene ID
- 3579
- UniProt ID
- P25025
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Single Domain Antibodies
Humanized Antibodies
Human Antibodies
IgG Antibodies
Neutralizing Antibodies
ScFv Antibodies
Fab Antibodies
Extracellular Vesicle Antibodies
IHC Kits & Antibodies
ScFv-Fc Chimeras
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-050 | Recombinant Anti-Human CXCR2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-002MZ-VHH | Anti-Human CXCR2 Recombinant Antibody (TAB-002MZ-VHH) | FC, Inhib | Single domain antibody |
| TAB-004MZ-VHH | Anti-Human CXCR2 Recombinant Antibody (TAB-004MZ-VHH) | ELISA, IHC, FuncS, SPR | Single domain antibody |
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For Research Use Only. Not For Clinical Use.
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