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    Anti-Human CXCR2 Recombinant Antibody (HY29) (CAT#: TAB-117MZ)

    This antibody is capable of binding to and modulating signaling from CXC chemokine receptor-2 (CXCR2) which may be used in treatment of cancers and inflammatory diseases.

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    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Published Data
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    FC

    Figure 1 Binding of HY29 to human neutrophils and neutrophils isolated from cynomolgus monkeys.

    Figure 1 Binding of HY29 to human neutrophils and neutrophils isolated from cynomolgus monkeys.

    FuncS

    Figure 2 Example of IL-8 dose response curves in the presence of increasing concentrations of HY29 Antibody.

    Figure 2 Example of IL-8 dose response curves in the presence of increasing concentrations of HY29 Antibody.

    Inhib

    Figure 3 HY29 Inhibition of Gro-cx and IL-8 driven human neutrophil chemotaxis

    Figure 3 HY29 Inhibition of Gro-cx and IL-8 driven human neutrophil chemotaxis

    FuncS

    Figure 4 Tumor growth inhibition in syngeneic mouse tumor models in human CXCR2 transgenic mice.

    Figure 4 Tumor growth inhibition in syngeneic mouse tumor models in human CXCR2 transgenic mice.

    FuncS

    Figure 5 Tumor growth inhibition in KRAS mutant lung cancer patient derived xenograft tumor model.

    Figure 5 Tumor growth inhibition in KRAS mutant lung cancer patient derived xenograft tumor model.

    FuncS

    Figure 6 HY29 inhibition of pancreatic cancer cell growth in 3D.

    Figure 6 HY29 inhibition of pancreatic cancer cell growth in 3D.

    The figure shows 14 day viability of four pancreatic tumor cell l ines in 3D matrigel overlay culture. Images were captured under phase contrast microscopy. Upper panel shows phase contrast micrograph, lower panel shows viability (left hand panel ) and 3D structure number ( right panel ). Significance was tested by one way ANOVA, error bars represent standard deviation.


    Specifications

    • Host Species
    • Human
    • Type
    • Humanized antibody
    • Specificity
    • Human
    • Clone
    • HY29
    • Applications
    • FC, FuncS, Inhib
    • Related Disease
    • Lymphoma, colon cancer, lung cancer, melanoma, or pancreatic cancer

    Applications

    • Application Notes
    • This antibody has been reported for use in Flow Cytotoxicityometry, Functional Assay, Inhibition.

    Target

    • Alternative Names
    • CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone HY29"

    See other products for "CXCR2"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    Single Domain Antibody Products Humanized Antibody Products Human Antibody Products IgG Antibody Products Neutralizing Antibody Products ScFv Antibody Products Fab Antibody Products Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    NABG-050 Recombinant Anti-Human CXCR2 VHH Single Domain Antibody ELISA, IHC, FC, FuncS Llama VHH
    TAB-002MZ-VHH Anti-Human CXCR2 Recombinant Antibody (TAB-002MZ-VHH) FC, Inhib Single domain antibody
    TAB-004MZ-VHH Anti-Human CXCR2 Recombinant Antibody (TAB-004MZ-VHH) ELISA, IHC, FuncS, SPR Single domain antibody

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    For Research Use Only. Not For Clinical Use.

    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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