Anti-Human CXCR2 Therapeutic Antibody (HY29)

Figure 1 Binding of HY29 to human neutrophils and neutrophils isolated from cynomolgus monkeys.

Figure 2 Example of IL-8 dose response curves in the presence of increasing concentrations of HY29 Antibody.

Figure 3 HY29 Inhibition of Gro-cx and IL-8 driven human neutrophil chemotaxis

Figure 4 Tumor growth inhibition in syngeneic mouse tumor models in human CXCR2 transgenic mice.

Figure 5 Tumor growth inhibition in KRAS mutant lung cancer patient derived xenograft tumor model.

Figure 6 HY29 inhibition of pancreatic cancer cell growth in 3D.

The figure shows 14 day viability of four pancreatic tumor cell l ines in 3D matrigel overlay culture. Images were captured under phase contrast microscopy. Upper panel shows phase contrast micrograph, lower panel shows viability (left hand panel ) and 3D structure number ( right panel ). Significance was tested by one way ANOVA, error bars represent standard deviation.