Recombinant Anti-DDR1 Vesicular Antibody, EV Displayed (VS-0425-YC431)
CAT#: VS-0425-YC431
The Recombinant Anti-DDR1 Vesicular Antibody, EV Displayed (VS-0425-YC431) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to DDR1-expressed cells or tissues. The DDR1 is a receptor for collagen-mediated signaling, influencing epithelial cell growth in several organs.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57194/if_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_A_9_8.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_B_7_5.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_A_5_6.jpg
Normal Tissue
Figure 6 Skin
Melanocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_B_7_1.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HaCaT, HBEC3-KT, RT4, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204580-DDR1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- DDR1
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Discoidin domain receptor tyrosine kinase 1
- Biological Process
- Lactation, Pregnancy
- Molecular Function
- Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Plasma membrane, Nucleoplasm, Cytosol
- Introduction
- Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
- Alternative Names
- CAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6
- Gene ID
- 780
- UniProt ID
- Q08345
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Datasheet
MSDS
COA
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See other products for "DDR1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-176MZ | Anti-Human DDR1 Recombinant Antibody (DDR1-ab1) | FuncS | Human antibody |
| TAB-176MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (DDR1-ab1) | IF | Human antibody |
| TAB-177MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (DDR1-ab2) | IF | Human antibody |
| TAB-178MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (DDR1-ab3) | IF | Human antibody |
| PABX-043-S (P) | Recombinant Mouse Anti-DDR1 Antibody scFv Fragment (3E3) | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0953 | Hi-Affi™ Rabbit Anti-DDR1 Recombinant Antibody (clone DS953AB) | ELISA, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0077-CN-F(E) | Human Anti-DDR1 Recombinant Antibody (clone APE05570); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0064-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2074); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0065-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2078); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0066-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2079); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0067-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2092); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0061-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026) | ELISA | Mouse IgG |
| HPAB-0062-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2039) | ELISA | Mouse IgG |
| HPAB-0063-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2031) | ELISA | Mouse IgG |
| HPAB-0064-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2074) | ELISA | Mouse IgG |
| HPAB-0065-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2078) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0061-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0062-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2039); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0063-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2031); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0064-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2074); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0065-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2078); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1235 | AbPlus™ Anti-DDR1 Magnetic Beads (VS-0724-YC1235) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY638 | Anti-DDR1 Immunohistochemistry Kit | IHC |
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