Recombinant Anti-DDR1 Vesicular Antibody, EV Displayed (VS-0425-YC431) (CAT#: VS-0425-YC431)

• Application
• ELISA, FC, Neut, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• DDR1

• Host Animal
• Mouse

• Antibody Isotype
• IgG

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Discoidin domain receptor tyrosine kinase 1

• Biological Process
• Lactation, Pregnancy

• Molecular Function
• Kinase, Receptor, Transferase, Tyrosine-protein kinase

• Cellular Localization
• Plasma membrane, Nucleoplasm, Cytosol

• Introduction
• Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

• Alternative Names
• CAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6

• Gene ID
• 780

• UniProt ID
• Q08345

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