Mouse Anti-DDR1 Recombinant Antibody (clone mAb 3E3) (CAT#: PABL-436)
Recombinant Mouse Antibody (mAb 3E3) is capable of binding to DDR1, expressed in Chinese Hamster Ovary cells (CHO). This antibody uses predominantly aromatic residues to recognize this epitope: Thr30, Phe32, Tyr34, Tyr49, and Leu50 of the light chain; and Ile31, Trp33, Tyr52, Tyr56, and Tyr96 of the heavy chain.
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Figure 1 The anti-DDR1 mAbs 3E3 block Collagen-induced DDR1 phosphorylation.
DDR1b was transiently expressed in HEK293 cells, and the cells were stimu- lated with 10 mg/ml collagen I in the absence or presence of 10 mg/ml of the indicated anti-DDR1 mAbs. Aliquots of cell lysates were analyzed by SDS- PAGE and western blotting. The blots were probed with anti-phosphotyrosine (anti-PY) mAb 4G10 (upper blot) and reprobed with anti-DDR1 Ab (lower blot). Control, mouse IgG1 isotype control Ab. The experiment was performed three times with similar results.
Carafoli, F., Mayer, M. C., Shiraishi, K., Pecheva, M. A., Chan, L. Y., Nan, R., ... & Hohenester, E. (2012). Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling. Structure, 20(4), 688-697.
Specifications
- Immunogen
- Human discoidin domain receptor tyrosine kinase 1
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human DDR1
- Species Reactivity
- Human
- Clone
- mAb 3E3
- Applications
- ELISA, FC
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- DDR1; discoidin domain receptor tyrosine kinase 1; CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A; epithelial discoidin domain-containing receptor 1; tyrosine kinase DDR; cell adhesion kinase; mammary carcinoma kinase 10; tyrosine-protein kinase CAK; protein-tyrosine kinase RTK-6; neuroepithelial tyrosine kinase; PTK3A protein tyrosine kinase 3A; CD167 antigen-like family member A; neurotrophic tyrosine kinase, receptor, type 4;
- Gene ID
- 780
- UniProt ID
- Q08345
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-433 | Mouse Anti-DDR1 Recombinant Antibody (clone mAb 3E3); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0077-CN-S(P) | Human Anti-DDR1 Recombinant Antibody (clone APE05570); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0078-CN-S(P) | Human Anti-DDR1 Recombinant Antibody (clone APE05571); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0061-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0062-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2039); scFv Fragment | ELISA | Mouse scFv |
Customer Reviews and Q&As
Customer Review
Q&As
High Conjugation Efficiency
The antibody conjugates efficiently with fluorophores and enzymes, ensuring high-quality results in varied assay setups. Very pleased with the conjugation process.
Good Batch Consistency
Each batch of this antibody that I've used has performed consistently, ensuring reliable and reproducible results over time. Batch-to-batch reliability is very high.
High Purity
The antibody purity is high, which is evident in its performance across different assays. It provides clean, interpretable data without contamination issues.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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