Recombinant Anti-ENG Vesicular Antibody, EV Displayed (VS-0425-YC237)

Name: Recombinant Anti-ENG Vesicular Antibody, EV Displayed (VS-0425-YC237)
SKU: VS-0425-YC237
Rating: 5 (1 reviews)

CAT#: VS-0425-YC237

The Recombinant Anti-ENG Vesicular Antibody, EV Displayed (VS-0425-YC237) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ENG-expressed cells or tissues. The ENG is a major endothelial glycoprotein, part of the TGF-beta receptor complex. Mutations cause hereditary hemorrhagic telangiectasia.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear bodies & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1823_F9_38_selected.jpg

Subcellular Location Figure 2 IHC staining of human placenta

Immunohistochemical staining of human placenta shows moderate membranous positivity in trophoblastic cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11862/158146_A_2_7_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to nuclear bodies & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1777_G1_13_cr59632eeaa8e82_blue_red_green.jpg

Subcellular Location Figure 4 IF staining of human cell line SiHa

Immunofluorescent staining of human cell line SiHa shows localization to nuclear bodies & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1759_C2_13_cr594b6f97edc10_blue_red_green.jpg

Normal Tissue Figure 5 Kidney

Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/156475_A_9_5.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (fHDF/TERT166, HUVEC TERT2, TIME)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106991-ENG

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Recombinant Antibody

Application
Cyt, ELISA, FC, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
ENG

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Endoglin

Biological Process
Angiogenesis, Cell adhesion

Cellular Localization
Plasma membrane

Introduction
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Alternative Names
CD105, END, HHT1, ORW, ORW1

Gene ID
2022

UniProt ID
P17813

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Downloadable Resources

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Datasheet

Datasheet - VS-0425-YC237.pdf

MSDS

MSDS - VS-0425-YC237.pdf

COA

Certificate of Analysis Lookup

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TAB-1574CL-F(E)	Mouse Anti-ENG Recombinant Antibody; Fab Fragment (TAB-1574CL-F(E))	FC	Mouse Fab

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HPAB-0713-CN-S(P)	Human Anti-ENG Recombinant Antibody (clone 6B10); scFv Fragment	WB, FC	Human scFv
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HPAB-0715-CN-F(E)	Human Anti-ENG Recombinant Antibody (clone 4.37); Fab Fragment	WB, FC	Human Fab
HPAB-0137-WJ-F(E)	Human Anti-ENG Recombinant Antibody; Fab Fragment (HPAB-0137-WJ-F(E))	ELISA	Humanized Fab
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AFC-TAB-013ML	Afuco™ Anti-ENG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-013ML)	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody

CAT	Product Name	Application
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MHC-CN0615	FITC-A*02:01/Human ENG (LLTAALWYV) MHC Tetramer	FCM, IHC
MHC-CN0616	A*02:01/Human ENG (LLTAALWYV) MHC Tetramer	FCM, IHC

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