Human Anti-ENG (clone 6B10) scFv-Fc Chimera (CAT#: VS-0325-FY146)

• Immunogen
• Stably transfected B300.19 cells expressing human CD105.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human ENG

• Species Reactivity
• Human

• Clone
• 6B10

• Applications
• Western Blot, Flow Cytometry, ADCC

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Flow Cytometry: 10 μg/mL
  Western Blot: 0.5-2 μg/mL

• Alternative Names
• Endoglin; CD105 Antigen; END; Osler-Rendu-Weber Syndrome 1; HHT1; ORW1

• Gene ID
• 2022

• UniProt ID
• P17813

• Long Name
• Endoglin

• Cellular Localization
• Cell membrane; Membrane

• Protein Refseq
• NP_000109.1; NP_001108225.1; NP_001265067.1

• Function
• Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529).
  Required for normal structure and integrity of adult vasculature (PubMed:7894484).
  Regulates the migration of vascular endothelial cells (PubMed:17540773).
  Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity).
  May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity).
  May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830).
  Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529).
  Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

• HPAB-0713-CN
• Human Anti-ENG Recombinant Antibody (clone 6B10)

• HPAB-0713-CN-S(P)
• Human Anti-ENG Recombinant Antibody (clone 6B10); scFv Fragment

• HPAB-0713-CN-F(E)
• Human Anti-ENG Recombinant Antibody (clone 6B10); Fab Fragment

• VS-1024-FY79
• Anti-ENG (clone 6B10) Recombinant Antibody Coupled Liposome (VS-1024-FY79)

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