Recombinant Rabbit Anti-IL1A Detection Antibody (clone R07-4C2) (CAT#: VS3-WK1707)
This antibody is a rabbit recombinant antibody against human IL1A. It was developed by immunization of rabbit with recombinant human IL1A protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. R09-1M1 and R07-4C2 were identified as antibody pair for sandwich ELISA. As a detection antibody, the clone R07-4C2 can be used in ELISA analysis to identify human IL1A.
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RNA Expression
Figure 1 RNA cell line category: Group enriched (HBEC3-KT, hTCEpi, hTERT-HME1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115008-IL1A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115008-IL1A
Specifications
- Immunogen
- Recombinant human IL1A protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IL1A
- Species Reactivity
- Human
- Clone
- R07-4C2
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Interleukin 1 Alpha
- Gene ID
- 3552
- UniProt ID
- P01583
- Long Name
- Interleukin 1 Alpha
- Sequence Similarities
- Belongs to the IL-1 family.
- Cellular Localization
- Cytoplasm, Nucleus, Secreted
- Post Translation Modifications
- Acetylated within its nuclear localization sequence, which impacts subcellular localization.
Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.
Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.
- Protein Refseq
- NP_000566.3
- Function
- Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1400z | Mouse Anti-IL1A Recombinant Antibody (clone 23C8) | ELISA, IHC, WB | Mouse IgG2a |
| MOB-0888CT | Recombinant Mouse anti-Rat IL1A Monoclonal antibody (60026.222) | ELISA, WB | |
| MRO-1961-CN | Rabbit Anti-IL1A Polyclonal Antibody (MRO-1961-CN) | IHC, FC, WB | Rabbit IgG |
| ZG-0497J | Mouse Anti-IL1A Recombinant Antibody (ZG-0497J) | WB, ELISA | Mouse IgG |
| VS-0923-FY99 | Recombinant Mouse Anti-IL1A Antibody (VS-0923-FY99) | ELISA, WB, IHC | Mouse IgG1 |
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