Recombinant Anti-IL21R Vesicular Antibody, EV Displayed (VS-0425-YC547)
CAT#: VS-0425-YC547
The Recombinant Anti-IL21R Vesicular Antibody, EV Displayed (VS-0425-YC547) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL21R-expressed cells or tissues. IL21R is a receptor for interleukin 21, important in T, B, and NK cell proliferation. It activates pathways like JAK-STAT and influences immunoglobulin production.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42296/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42296/94512_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42296/94512_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42296/94512_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42296/94512_A_6_6.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42296/94512_B_6_4.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42296/94512_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, RH-30, RPMI-8226, U-266/70)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000103522-IL21R
❮
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL21R
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Cynomolgus, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 21 receptor
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Cytosol
- Introduction
- The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
- Alternative Names
- CD360
- Gene ID
- 50615
- UniProt ID
- Q9HBE5
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Datasheet
MSDS
COA
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See other products for "IL21R"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-583LC | Rat Anti-IL21R Recombinant Antibody (TAB-583LC) | ELISA, WB | Rat IgG |
| TAB-584LC | Rat Anti-IL21R Recombinant Antibody (TAB-584LC) | ELISA, WB | Rat IgG |
| TAB-583LC-S(P) | Rat Anti-IL21R Recombinant Antibody; scFv Fragment (TAB-583LC-S(P)) | ELISA, WB | Rat scFv |
| TAB-584LC-S(P) | Rat Anti-IL21R Recombinant Antibody; scFv Fragment (TAB-584LC-S(P)) | ELISA, WB | Rat scFv |
| TAB-583LC-F(E) | Rat Anti-IL21R Recombinant Antibody; Fab Fragment (TAB-583LC-F(E)) | ELISA, WB | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-585LC | Human Anti-IL21R Recombinant Antibody (TAB-585LC) | ELISA, FC | Human IgG2, κ |
| TAB-586LC | Human Anti-IL21R Recombinant Antibody (TAB-586LC) | ELISA, FC | Human IgG2, κ |
| TAB-587LC | Human Anti-IL21R Recombinant Antibody (TAB-587LC) | ELISA, FC | Human IgG2, κ |
| TAB-588LC | Anti-human IL21R Recombinant Antibody (MUF) (TAB-588LC) | ELISA, FC, Block | Human antibody |
| TAB-589LC | Anti-human IL21R Recombinant Antibody (MU11) (TAB-589LC) | ELISA, FC, Block | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1327CQ | Rat Anti-Il21r Recombinant Antibody (VMC196) | Block | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4261 | Rabbit Anti-IL21R Recombinant Antibody (clone SI341DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0668-CN | Human Anti-Il21r Recombinant Antibody (clone 18A5) | FC, IHC | Human IgG1 |
| HPAB-0669-CN | Human Anti-IL21R Recombinant Antibody (clone ABS) | ELISA, FC, Neut | Human IgG |
| HPAB-0247CQ | Human Anti-IL21R Recombinant Antibody (clone 19F5) | Neut, WB, ELISA, FC, IHC | Human IgG1 |
| FAMAB-1203CQ | Human Anti-IL21R Recombinant Antibody (clone ATR-107) | Inhib, FC, WB | Human IgG1 |
| VS-0723-WK200 | Human Anti-IL21R Recombinant Antibody (VS-0723-WK200) | ELISA, FC | Chimeric (rabbit/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0668-CN-S(P) | Human Anti-IL21R Recombinant Antibody (clone 18A5); scFv Fragment | ELISA, FC, Neut | Human scFv |
| HPAB-0669-CN-S(P) | Human Anti-IL21R Recombinant Antibody (clone ABS); scFv Fragment | ELISA, FC, Neut | Human scFv |
| HPAB-0247CQ-S(P) | Human Anti-IL21R Recombinant Antibody (clone 19F5); scFv Fragment | ELISA, FC, Inhib | Human scFv |
| HPAB-AP685-YC-S(P) | Human Anti-IL21R Recombinant Antibody (clone C2); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0668-CN-F(E) | Human Anti-IL21R Recombinant Antibody (clone 18A5); Fab Fragment | ELISA, FC, Neut | Human Fab |
| HPAB-0669-CN-F(E) | Human Anti-IL21R Recombinant Antibody (clone ABS); Fab Fragment | ELISA, FC, Neut | Human Fab |
| HPAB-0247CQ-F(E) | Human Anti-IL21R Recombinant Antibody (clone 19F5); Fab Fragment | ELISA, FC, Inhib | Human Fab |
| HPAB-AP685-YC-F(E) | Human Anti-IL21R Recombinant Antibody (clone C2); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY133 | CytoStream™ Mouse Anti-IL21R Recombinant Antibody (VS-0225-XY133) | FC | Mouse IgG1, kappa |
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