Recombinant Anti-ITGB2 Vesicular Antibody, EV Displayed (VS-0425-YC336) (CAT#: VS-0425-YC336)
The Recombinant Anti-ITGB2 Vesicular Antibody, EV Displayed (VS-0425-YC336) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ITGB2-expressed cells or tissues. The ITGB2 is an integrin beta chain crucial for immune response, with defects causing leukocyte adhesion deficiency.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg
Figure 2 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg
Figure 3 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg
Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ITGB2
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Integrin subunit beta 2
- Biological Process
- Cell adhesion, Phagocytosis
- Molecular Function
- Integrin, Receptor
- Cellular Localization
- Plasma membrane, Rods & Rings
- Introduction
- This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants.
- Alternative Names
- CD18, LFA-1, MAC-1, MFI7
- Gene ID
- 3689
- UniProt ID
- P05107
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-980 | Recombinant Mouse Anti-Human ITGB2 Antibody F(ab')2 Fragment, clone IB4 | FC, Inhib | F(ab')2 |
| HPAB-1207WJ-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone pxCD18-7T3); Fab Fragment | ELISA | Human Fab |
| HPAB-1874-FY-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone NA-8); Fab Fragment | Block | Humanized Fab |
| HPAB-1376WJ-F(E) | Human Anti-ITGB2 Recombinant Antibody; Fab Fragment (clone huH52) | ELISA, WB | Human Fab |
| HPAB-1569WJ-F(E) | Mouse Anti-ITGB2 Recombinant Antibody; Fab Fragment (clone 1B4) | ELISA, WB, IF | Mouse Fab |
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