Recombinant Anti-ITGB2 Vesicular Antibody, EV Displayed (VS-0425-YC336) (CAT#: VS-0425-YC336)
The Recombinant Anti-ITGB2 Vesicular Antibody, EV Displayed (VS-0425-YC336) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ITGB2-expressed cells or tissues. The ITGB2 is an integrin beta chain crucial for immune response, with defects causing leukocyte adhesion deficiency.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg
Figure 2 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg
Figure 3 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg
Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
Figure 4 RNA cell line category: Group enriched (THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ITGB2
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Integrin subunit beta 2
- Biological Process
- Cell adhesion, Phagocytosis
- Molecular Function
- Integrin, Receptor
- Cellular Localization
- Plasma membrane, Rods & Rings
- Introduction
- This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants.
- Alternative Names
- CD18, LFA-1, MAC-1, MFI7
- Gene ID
- 3689
- UniProt ID
- P05107
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-099 | Recombinant Anti-Human ITGB2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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