Anti-Human ITGB2 Recombinant Antibody (Hu23F2G (also known as LeukArrest and Rovelizumab)) (CAT#: TAB-1582CL)
This antibody is a humanized antibody Hu23F2G, also known as LeukArrest and Rovelizumab. Hu23F2G reacts with the common β chain (CD18) of human leukocyte integrins and competes with mAb 60.3 for binding to human LFA-1, which is useful for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory processes associated with the multiple sclerosis disease.
Specific Inquiry
IP
Figure 1 Polyacrylamide gel electrophoresis (PAGE) shows immunoprecipitation of β2 integrins by Hu23F2G in rabbit leukocytes.
The band at 150-180 kDa represents the CD11 chain, and the 90-to 100-kDa chain represents the CD18 chain. The control lane represents leukocytes incubated with human IgG4.
Yenari, M. A., Kunis, D., Sun, G. H., Onley, D., Watson, L., Turner, S.,... & Steinberg, G. K. (1998). Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. Experimental neurology, 153(2), 223-233.
FuncS
Figure 2 Hu23F2G treatment reduces the percentage area of ischemic neuronal damage (IND) within the ipsilateral (a) hemisphere and (b) cortex in 4 coronal levels, and levels 1-4 combined, but does not appear to affect the striatum (c).
Hu23F2G was administered 4 mg/kg i.v., starting 20 min after onset of ischemia; n=8 for Hu23F2G and n=7 for saline. IND, ischemic neuronal damage; *P<0.05, t test.
Yenari, M. A., Kunis, D., Sun, G. H., Onley, D., Watson, L., Turner, S.,... & Steinberg, G. K. (1998). Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. Experimental neurology, 153(2), 223-233.
FuncS
Figure 3 Representative sections from ischemic cortex in control (a) and Hu23F2G treated (b) animals showing the presence of neutrophils in a control animal (arrows) compared to a complete lack of neutrophil infiltration in the treated animal.
Neutrophils are seen within microvessels of a control animal (a, arrowheads), but not in a treated one (b, arrowheads) (neutrophil elastase immunostain, 50×).
Yenari, M. A., Kunis, D., Sun, G. H., Onley, D., Watson, L., Turner, S.,... & Steinberg, G. K. (1998). Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. Experimental neurology, 153(2), 223-233.
FuncS
Figure 4 Neutrophil infiltration is reduced in animals treated with Hu23F2G.
Data are shown normalized to the corrected IND area (cm⁻²). IND, ischemic neuronal damage. *P=0.001, t test.
Yenari, M. A., Kunis, D., Sun, G. H., Onley, D., Watson, L., Turner, S.,... & Steinberg, G. K. (1998). Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. Experimental neurology, 153(2), 223-233.
FuncS
Figure 5 Percentage area of ischemic edema.
Hu23F2G administered at 4 mg/kg i.v., starting 20 min after onset of ischemia; n=8 for Hu23F2G and n=7 for saline. P=0.09, t test.
Yenari, M. A., Kunis, D., Sun, G. H., Onley, D., Watson, L., Turner, S.,... & Steinberg, G. K. (1998). Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. Experimental neurology, 153(2), 223-233.
Specifications
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- Hu23F2G (also known as LeukArrest and Rovelizumab)
- Applications
- IP, FuncS
- Related Disease
- Inflammatory disease
Applications
- Application Notes
- This antibody has been tested for use in Immunoprecipitation and Functional Assay.
Target
- Alternative Names
- ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1; integrin beta-2; integrin beta chain, beta 2; complement receptor C3 beta-subunit; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoprotein (LFA-1/CR3/P150, 959 beta subunit precursor)
- Gene ID
- 3689
- UniProt ID
- B4E0R1
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone Hu23F2G (also known as LeukArrest and Rovelizumab)"
- TAB-1582CL-S(P)
- Anti-Human ITGB2 Recombinant Antibody scFv Fragment (Hu23F2G (also known as LeukArrest and Rovelizumab))
See other products for "ITGB2"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-099 | Recombinant Anti-Human ITGB2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-044 | Anti-Human ITGB2 Recombinant Antibody (Rovelizumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG4 |
| TAB-154-F(E) | Anti-Human CD18 Recombinant Antibody F(ab')2 Fragment( Erlizumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 |
| TAB-461CL | Human Anti-ITGB2 Recombinant Antibody (TAB-461CL) | ELISA | Human IgG |
| TAB-1582CL-S(P) | Anti-Human ITGB2 Recombinant Antibody scFv Fragment (Hu23F2G (also known as LeukArrest and Rovelizumab)) | Inhib | Humanized antibody |
| TAB-1582CL-F(E) | Anti-Human ITGB2 Recombinant Antibody Fab Fragment (Hu23F2G (also known as LeukArrest and Rovelizumab)) | Inhib | Humanized antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1581CL | Anti-Human ITGB2 Recombinant Antibody (23F2G) | Inhib | |
| TAB-1581CL-S(P) | Anti-Human ITGB2 Recombinant Antibody scFv Fragment (23F2G) | Inhib | |
| TAB-1581CL-F(E) | Anti-Human ITGB2 Recombinant Antibody Fab Fragment (23F2G) | Inhib |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0298MZ | Chicken Anti-ITGB2 Polyclonal IgY | WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1590CQ | Recombinant Mouse Anti-ITGB2 Antibody (MEM-48) | BL, FC, IHC-Fr, IHC-P, IP, WB | IgG1 |
| NEUT-1591CQ | Recombinant Mouse Anti-ITGB2 Antibody (TS1/18) | BL, FC, ICC/IF, IHC, WB | IgG1 |
| NEUT-1592CQ | Recombinant Mouse Anti-ITGB2 Antibody (YFC118.12) | FC, BL | IgG1, κ |
| NEUT-1593CQ | Recombinant Mouse Anti-ITGB2 Antibody (MEM-148) | FC, IP, WB, BL, FuncS | IgG1 |
| NEUT-1594CQ | Recombinant Hamster Anti-Itgb2 Antibody (2E6) | BL, ICC, IP, FC | IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1884 | Hi-Affi™ Recombinant Rabbit Anti-ITGB2 Monoclonal Antibody (DS1884AB) | IP, WB | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203CQ-F(E) | Mouse Anti-ITGB2 Recombinant Antibody (clone 60.3); Fab Fragment | ELISA, WB, Block | Mouse Fab |
| FAMAB-0204CQ-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone h60.3); Fab Fragment | ELISA, WB, Block | Human Fab |
| HPAB-1769-FY-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone D2-57); Fab Fragment | ELISA | Human Fab |
| HPAB-1770-FY-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone DX-2001); Fab Fragment | ELISA | Human Fab |
| HPAB-1771-FY-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone C1-54); Fab Fragment | ELISA | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0801-CN-S(P) | Recombinant Mouse Anti-ITGB2 Antibody scFv Fragment (CBCNC1) | ELISA, IHC | Mouse scFv |
| HPAB-1769-FY-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone D2-57); scFv Fragment | ELISA | Human scFv |
| HPAB-1770-FY-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone DX-2001); scFv Fragment | ELISA | Human scFv |
| HPAB-1771-FY-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone C1-54); scFv Fragment | ELISA | Human scFv |
| HPAB-1207WJ-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone pxCD18-7T3); scFv Fragment | ELISA | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-044 | Afuco™ Anti-ITGB2 ADCC Recombinant Antibody (Rovelizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1292WJ | Rat Anti-ITGB2 Recombinant Antibody (clone YFC51.1) | ELISA, FC | Rat IgG |
| HPAB-1293WJ | Human Anti-ITGB2 Recombinant Antibody (clone LDP-01) | ELISA, FC | Humanized IgG |
| HPAB-1874-FY | Human Anti-ITGB2 Recombinant Antibody (clone NA-8) | Block | Human IgG1 |
| HPAB-1376WJ | Human Anti-ITGB2 Recombinant Antibody (clone huH52) | ELISA, WB | Human IgG2 |
| HPAB-1569WJ | Mouse Anti-ITGB2 Recombinant Antibody (clone 1B4) | ELISA, WB, IF | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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