Afuco™ Anti-ITGB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-044)

Name: Afuco™ Anti-ITGB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-044)
SKU: AFC-TAB-044
Rating: 5 (1 reviews)

CAT#: AFC-TAB-044

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD18. It is a humanized monoclonal antibody which was an experimental immunosuppressive drug. The drug is a monoclonal antibody that suppresses white blood cells which become overly active during shock.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/202_B8_2_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line EFO-21

Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/131_C9_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line BJ

Immunofluorescent staining of human cell line U-4 OS shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16894/1842_G1_63_blue_red_green.jpg

RNA Expression Figure 4 RNA cell line category: Group enriched (THP-1, U-937)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160255-ITGB2

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Humanized (from mouse)

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
Neut, ELISA, IF, IP, FuncS, FC

Conjugate
Unconjugated

Trade name
Leukarrest

Generic Name
Rovelizumab

Related Disease
Ischemic stroke

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); CD18, integrin, beta 2 (antigen CD18 (p95), lymphocyte function associated antigen 1;

Gene ID
3689

UniProt ID
P05107

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Biosimilar Overview

Please refer to Rovelizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Rovelizumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-044.pdf

MSDS

MSDS - AFC-TAB-044.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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