Recombinant Anti-MADCAM1 Vesicular Antibody, EV Displayed (VS-0425-YC440)

Name: Recombinant Anti-MADCAM1 Vesicular Antibody, EV Displayed (VS-0425-YC440)
SKU: VS-0425-YC440
Rating: 5 (1 reviews)

CAT#: VS-0425-YC440

The Recombinant Anti-MADCAM1 Vesicular Antibody, EV Displayed (VS-0425-YC440) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MADCAM1-expressed cells or tissues. The MADCAM1 is an adhesion molecule directing leukocytes to mucosal tissues, with several isoforms identified.

Gene Expression

Normal Tissue Figure 1 IHC staining of human appendix

Immunohistochemical staining of human appendix shows strong cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/77998/169642_A_3_2_selected.jpg

Normal Tissue Figure 2 Appendix

High expression

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_2_2_val_selected.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes -

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_8_3.jpg

Normal Tissue Figure 4 Liver

Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_7_4.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_6_6.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (HEK93, Hep G2, U-266/70)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099866-MADCAM1

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Recombinant Antibody

Application
Block, ELISA, FC, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
MADCAM1

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Mucosal vascular addressin cell adhesion molecule 1

Biological Process
Cell adhesion

Introduction
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.

Alternative Names
MACAM1

Gene ID
8174

UniProt ID
Q13477

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Datasheet

Datasheet - VS-0425-YC440.pdf

MSDS

MSDS - VS-0425-YC440.pdf

COA

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