Recombinant Anti-MADCAM1 Vesicular Antibody, EV Displayed (VS-0425-YC440)
CAT#: VS-0425-YC440
The Recombinant Anti-MADCAM1 Vesicular Antibody, EV Displayed (VS-0425-YC440) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MADCAM1-expressed cells or tissues. The MADCAM1 is an adhesion molecule directing leukocytes to mucosal tissues, with several isoforms identified.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human appendix
Immunohistochemical staining of human appendix shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/77998/169642_A_3_2_selected.jpg
Normal Tissue
Figure 2 Appendix
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_2_2_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes -
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_7_4.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HEK93, Hep G2, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099866-MADCAM1
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Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MADCAM1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Mucosal vascular addressin cell adhesion molecule 1
- Biological Process
- Cell adhesion
- Introduction
- The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
- Alternative Names
- MACAM1
- Gene ID
- 8174
- UniProt ID
- Q13477
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| HPAB-0041-DJB-F(E) | Human Anti-MADCAM1 Recombinant Antibody; Fab Fragment (HPAB-0041-DJB-F(E)) | ELISA | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-635 | Mouse Anti-MADCAM1 Recombinant Antibody (clone 10G3); scFv Fragment | WB, IF, FuncS | Mouse scFv |
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| HPAB-0041-DJB-S(P) | Human Anti-MADCAM1 Recombinant Antibody; scFv Fragment (HPAB-0041-DJB-S(P)) | ELISA | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0714CL | Anti-Mouse Madcam1 Recombinant Antibody (MECA-367) | ELISA | |
| TAB-0714CL-S(P) | Anti-Mouse Madcam1 Recombinant Antibody scFv Fragment (MECA-367) | ELISA | |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-051CN | Human Anti-MADCAM1 Recombinant Antibody (NS-051CN) | ELISA, WB, IHC, FC, Block, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1284 | Anti-MAdCAM1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4162 | Anti-Human MADCAM1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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