Human Anti-MADCAM1 scFv-Fc Chimera (VS-0425-FY154) (CAT#: VS-0425-FY154)
The anti-MADCAM1 scFv-FC is a recombinant fusion protein that combines a single-chain variable fragment (scFv) targeting the mucosal addressin cell adhesion molecule 1 (MADCAM1) with a fragment crystallizable (FC) region of an antibody. MADCAM1 is primarily expressed in endothelial cells of the gastrointestinal tract and plays a crucial role in lymphocyte homing and adhesion to the gut. This scFv-FC product is designed for therapeutic applications, potentially modulating immune responses in inflammatory bowel disease and other gastrointestinal disorders.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human appendix
(Immunohistochemical staining of human appendix shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77998/169642_A_3_2_selected.jpg
(Immunohistochemical staining of human appendix shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77998/169642_A_3_2_selected.jpg
Figure 2 Appendix
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_2_2_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_2_2_val_selected.jpg
Figure 3 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes -)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_8_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes -)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_8_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_7_4.jpg
(Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_7_4.jpg
Figure 5 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_6_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (HEK93, Hep G2, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099866-MADCAM1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099866-MADCAM1
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MADCAM1
- Species Reactivity
- Human
- Applications
- Immunohistochemistry
- Related Disease
- Cardiovascular disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Mucosal Vascular Addressin Cell Adhesion Molecule 1; HMAdCAM-1; MAdCAM-1; Mucosal Addressin Cell Adhesion Molecule-1; Mucosal Addressin Cell Adhesion Molecule 1; MACAM1
- Gene ID
- 8174
- UniProt ID
- Q13477
- Long Name
- Mucosal Vascular Addressin Cell Adhesion Molecule 1
- Cellular Localization
- Membrane
- Post Translation Modifications
- The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
- Protein Refseq
- NP_570116.2; NP_570118.1
- Function
- Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1935z | Mouse Anti-MADCAM1 Recombinant Antibody (MOB-1935z) | IHC, IF, ELISA | Mouse IgG2a |
| PABL-640 | Mouse Anti-MADCAM1 Recombinant Antibody (clone 10G3) | WB, IF, FuncS | Mouse IgG |
| MOB-1116CT | Recombinant Mouse anti-Human MADCAM1 Monoclonal antibody (28G6) | FC | |
| HPAB-692-FY | Mouse Anti-MADCAM1 Recombinant Antibody (HPAB-692-FY) | ELISA | Mouse IgG |
| VS4-CJ24 | Recombinant Rabbit Anti-MADCAM1 Antibody (clone 12B5) | ELISA, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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