Human Anti-MADCAM1 Recombinant Antibody (clone PF-547659) (CAT#: PABL-641)
Recombinant Human Antibody (PF-547659) is capable of binding to MAdCAM-1 D1D2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-MAdCAM-1 D1D2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-MAdCAM-1 D1D2 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Figure 1 Interface between D1 and D2 in MAdCAM and VCAM.
A and B show the most dissimilar native MAdCAM interfaces in the 1.7-Å structure (A) and chain B in complex with PF-547659 (B).
Yu, Y., Zhu, J., Huang, P. S., Wang, J. H., Pullen, N., & Springer, T. A. (2013). Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop. Journal of Biological Chemistry, 288(9), 6284-6294.
Specifications
- Immunogen
- Human mucosal vascular addressin cell adhesion molecule 1
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG
- Specificity
- Human MADCAM1
- Species Reactivity
- Human
- Clone
- PF-547659
- Applications
- WB, IF, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- MACAM1; MADCAM1; mucosal vascular addressin cell adhesion molecule 1
- Gene ID
- 8174
- UniProt ID
- Q13477
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1935z | Mouse Anti-MADCAM1 Recombinant Antibody (MOB-1935z) | IHC, IF, ELISA | Mouse IgG2a |
| HPAB-0040-DJB | Human Anti-MADCAM1 Recombinant Antibody (HPAB-0040-DJB) | ELISA | Human IgG2, κ |
| HPAB-0041-DJB | Human Anti-MADCAM1 Recombinant Antibody (HPAB-0041-DJB) | ELISA | Human IgG4, κ |
| HPAB-0042-DJB | Human Anti-MADCAM1 Recombinant Antibody (HPAB-0042-DJB) | ELISA | Human IgG4, κ |
| FAMAB-1428CQ | Mouse Anti-MADCAM1 Recombinant Antibody (clone MECA-367) | IP, WP, Block, FC, IHC | Mouse IgG2a |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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