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MADCAM1

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Endothelial cells, Bipolar cells, Rod photoreceptor cells, Muller glia cells)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enhanced (HEK93, Hep G2, U-266/70)

Interaction

Homodimer.

More Types Infomation

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