Recombinant Anti-MOG Vesicular Antibody, EV Displayed (VS-0425-YC509)

CAT#: VS-0425-YC509

The Recombinant Anti-MOG Vesicular Antibody, EV Displayed (VS-0425-YC509) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MOG-expressed cells or tissues. MOG facilitates response activities like folic acid reaction and is linked to optic neuritis, multiple sclerosis, and narcolepsy.

Gene Expression
Figure 1 IHC staining of human cerebral cortex Figure 2 IHC staining of human pancreas Figure 3 Colon Figure 4 Testis

Recombinant Antibody

  • Application
  • ELISA, FC, Neut, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • MOG
  • Host Animal
  • Human
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Rat
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • z domain
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Binding Affinity
  • Kd = 0.85 µg/mL
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Myelin oligodendrocyte glycoprotein
  • Biological Process
  • Cell adhesion, Host-virus interaction
  • Molecular Function
  • Host cell receptor for virus entry, Receptor
  • Introduction
  • Predicted to enable signaling receptor binding activity. Involved in response to folic acid and response to lipid. Located in cell surface. Used to study optic neuritis. Human ortholog(s) of this gene implicated in multiple sclerosis; narcolepsy; and optic neuritis. Orthologous to human MOG (myelin oligodendrocyte glycoprotein).
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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