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The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein class

Disease related genes, Human disease related genes

Predicted location


Single cell type specificity

Cell type enriched (Oligodendrocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected


Homodimer (By similarity). May form heterodimers between the different isoforms (By similarity). (Microbial infection) Interacts with rubella virus E2 glycoprotein.

Molecular function

Host cell receptor for virus entry, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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