Recombinant Mouse Anti-NGFR Antibody (clone 8G8H10) (CAT#: VS3-FY1042)
This product is a recombinant mouse antibody that recognizes NGFR. This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Flow Cytometry. The clone 8G8H10 is specific for NGFR.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4765/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4765/if_selected.jpg
Figure 2 Adrenal gland
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4765/15396_B_6_5_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4765/15396_B_6_5_val_selected.jpg
Figure 3 Colon
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1995/5109_A_9_3.jpg
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1995/5109_A_9_3.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/143/2551_A_9_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/143/2551_A_9_5.jpg
Figure 5 RNA cell line category: Group enriched (RH-30, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000064300-NGFR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000064300-NGFR
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Clone
- 8G8H10
- Applications
- Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Flow Cytometry
- Conjugate
- Unconjugated
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Flow Cytometry.
Target
- Alternative Names
- Nerve Growth Factor Receptor; Low Affinity Neurotrophin Receptor P75NTR; Low-Affinity Nerve Growth Factor Receptor; TNFR Superfamily, Member 16; NGF Receptor; Gp80-LNGFR; TNFRSF16; P75 ICD
- Gene ID
- 4804
- UniProt ID
- P08138
- Cellular Localization
- Cell membrane, Cell projection, Membrane, Synapse
- Post Translation Modifications
- N- and O-glycosylated.
O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
Phosphorylated on serine residues.
- Protein Refseq
- NP_002498.1
- Function
- Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).
Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity).
Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181).
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity).
Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "NGFR"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1958z | Mouse Anti-NGFR Recombinant Antibody (clone 32C5) | WB, FC, ICC, IHC | Mouse IgG1 |
| MOB-1877MZ | Recombinant Mouse Anti-Human NGFR Antibody (clone OHGS6) | FC, ICC/IF, IHC-P | Mouse antibody |
| HPAB-0276CQ | Mouse Anti-NGFR Recombinant Antibody (clone MC192) | ELISA, IHC, IP, IF, WB, FuncS | Mouse IgG1 |
| MRO-1158-CN | Recombinant Rabbit Anti-NGFR Monoclonal Antibody (CBACN-421) | WB, IF, IHC, IP | Rabbit IgG |
| VS3-XY1166 | Mouse Anti-NGFR Recombinant Antibody (clone 2G2) | WB, IP, IF | Mouse IgG1 |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L038S | anti-Ngfr immunotoxin MC-192 (IgG)-Sap | Cytotoxicity assay, Functional assay |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1778CQ | Recombinant Mouse Anti-NGFR Antibody (ME20.4) | EM, ELISA, FC, ICC/IF, IHC-P, Inhib, IP, RIA, WB | IgG1 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1779CQ | Recombinant Mouse Anti-NGFR Antibody (5H1) | IHC, IP, Neut, WB | IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2440 | Hi-Affi™ Recombinant Rabbit Anti-NGFR Monoclonal Antibody (DS2440AB) | IHC-P | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0276CQ-F(E) | Mouse Anti-NGFR Recombinant Antibody (clone MC192); Fab Fragment | ELISA, IHC, IP, WB | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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