Recombinant Mouse Anti-NGFR Antibody (clone 8G8H10)
CAT#: VS3-FY1042
This product is a recombinant mouse antibody that recognizes NGFR. This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Flow Cytometry. The clone 8G8H10 is specific for NGFR.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4765/if_selected.jpg
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Clone
- 8G8H10
- Applications
- Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Flow Cytometry
- Conjugate
- Unconjugated
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Flow Cytometry.
Target
- Alternative Names
- Nerve Growth Factor Receptor; Low Affinity Neurotrophin Receptor P75NTR; Low-Affinity Nerve Growth Factor Receptor; TNFR Superfamily, Member 16; NGF Receptor; Gp80-LNGFR; TNFRSF16; P75 ICD
- Gene ID
- 4804
- UniProt ID
- P08138
- Cellular Localization
- Cell membrane, Cell projection, Membrane, Synapse
- Post Translation Modifications
- N- and O-glycosylated.
O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
Phosphorylated on serine residues.
- Protein Refseq
- NP_002498.1
- Function
- Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).
Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity).
Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181).
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity).
Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "NGFR"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1958z | Mouse Anti-NGFR Recombinant Antibody (clone 32C5) | WB, FC, ICC, IHC | Mouse IgG1 |
| MRO-1158-CN | Recombinant Rabbit Anti-NGFR Monoclonal Antibody (CBACN-421) | WB, IF, IHC, IP | Rabbit IgG |
| VS3-CJ486 | Rabbit Anti-NGFR Recombinant Antibody (VS3-CJ486) | WB, ICC, IF, IHC, IP | Rabbit IgG |
| VS13-YC806 | Rabbit Anti-NGFR Recombinant Antibody (VS13-YC806) | WB, IHC-P, ICC, IF, IP | Rabbit IgG |
| VS7-0425-WR481 | Mouse Anti-NGFR Monoclonal Antibody (VS7-0425-WR481) | WB, IF, ICC, FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L038S | anti-Ngfr immunotoxin MC-192 (IgG)-Sap | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1778CQ | Recombinant Mouse Anti-NGFR Antibody (ME20.4) | EM, ELISA, FC, ICC, IF, IHC-P, Inhib, IP, RIA, WB | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1779CQ | Recombinant Mouse Anti-NGFR Antibody (5H1) | IHC, IP, Neut, WB | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2440 | Hi-Affi™ Recombinant Rabbit Anti-NGFR Monoclonal Antibody (DS2440AB) | IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0276CQ-F(E) | Mouse Anti-NGFR Recombinant Antibody (clone MC192); Fab Fragment | ELISA, IHC, IP, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY203 | AbPlus™ Anti-NGFR Magnetic Beads (MC192) | IP, Protein Purification | |
| VS-0724-YC1307 | AbPlus™ Anti-NGFR Magnetic Beads (VS-0724-YC1307) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY341 | Mouse Anti-NHP NGFR Recombinant Antibody (clone NGFR5) | WB, IF, FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC590 | Recombinant Anti-NGFR Vesicular Antibody, EV Displayed (VS-0425-YC590) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4831 | Anti-NGFR Immunohistochemistry Kit | IHC |
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