Recombinant Anti-NRG1 Vesicular Antibody, EV Displayed (VS-0425-YC115)
CAT#: VS-0425-YC115
The Recombinant Anti-NRG1 Vesicular Antibody, EV Displayed (VS-0425-YC115) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to NRG1-expressed cells or tissues. The NRG1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. These isoforms are expressed in a tissue-specific manner, differing significantly in their structure and classified into types I, II, III, IV, V, and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/1446_D11_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human caudate
Immunohistochemical staining of human caudate shows weak positivity.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_7_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_7_5.jpg
Normal Tissue
Figure 4 Cerebellum
Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Purkinje cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_8.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_A_7_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A549, BJ, fHDF/TERT166, GAMG, U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000157168-NRG1
❮
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Recombinant Antibody
- Application
- ELISA, FC, SPR, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- NRG1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Neuregulin 1
- Molecular Function
- Growth factor
- Cellular Localization
- Nucleoplasm
- Introduction
- The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
- Alternative Names
- GGF, HGL, HRG, NDF, NRG1-IT2
- Gene ID
- 211323
- UniProt ID
- Q02297
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Related Signaling Pathways
ErbB Signaling Pathway
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COA
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| VS-0224-FY18 | Mouse Anti-NRG1 Recombinant Antibody (VS-0224-FY18) | WB, IHC, IP | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-579MZ | Mouse Anti-NRG1 Recombinant Antibody (TAB-579MZ) | ELISA, FC, WB | Mouse IgG |
| TAB-579MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-579MZ-S(P)) | ELISA, FC | Mouse scFv |
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| TAB-581MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-581MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-582MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-582MZ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-583MZ | Human Anti-NRG1 Recombinant Antibody (TAB-583MZ) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| TAB-584MZ | Human Anti-NRG1 Recombinant Antibody (TAB-584MZ) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| TAB-583MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-583MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-584MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-584MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-585MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-585MZ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-586MZ | Anti-Human NRG1 Recombinant Antibody (538.24) | ELISA, Inhib, SPR | Human antibody |
| TAB-587MZ | Anti-Human NRG1 Recombinant Antibody (538.24.71) | ELISA, Inhib, SPR, FuncS | Human antibody |
| TAB-586MZ-S(P) | Anti-Human NRG1 Recombinant Antibody scFv Fragment (538.24) | ELISA | Human antibody |
| TAB-587MZ-S(P) | Anti-Human NRG1 Recombinant Antibody scFv Fragment (538.24.71) | ELISA | Human antibody |
| TAB-588MZ-S(P) | Anti-Human NRG1 Recombinant Antibody scFv Fragment (526.9) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4349 | Hi-Affi™ Recombinant Rabbit Anti-NRG1 Monoclonal Antibody (SI439DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY26 | Human Anti-NRG1 (clone 526.9) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4980 | Anti-NRG1 Immunohistochemistry Kit | IHC |
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