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    NRG1

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    For Research Use Only. Not For Clinical Use.


    The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
    Protein class

    Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins

    Predicted location

    Intracellular, Membrane, Secreted (different isoforms)

    Single cell type specificity

    Group enriched (Excitatory neurons, Inhibitory neurons)

    Immune cell specificity

    Immune cell enriched (classical monocyte)

    Cell line specificity

    Cell line enhanced (A549, BJ, fHDF/TERT166, GAMG, U-2197)

    Interaction

    The cytoplasmic domain interacts with the LIM domain region of LIMK1 (By similarity). Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).

    Molecular function

    Growth factor

    More Types Infomation
    Related Signaling Pathways
    ErbB Signaling Pathway ErbB Signaling Pathway
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