Anti-Human NRG1 Recombinant Antibody (538.24.71) (CAT#: TAB-587MZ)
This anti-neuregulin 1 antibody can bind to both neuregulin-1α and neuregulin-1β isoforms. It can be potentially used in treating diseases or disorders, such as cancer.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/1446_D11_3_selected.jpg
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/1446_D11_3_selected.jpg
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows weak positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_7_selected.jpg
(Immunohistochemical staining of human caudate shows weak positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_7_selected.jpg
Figure 3 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_7_5.jpg
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_7_5.jpg
Figure 4 Cerebellum
(Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Purkinje cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_8.jpg
(Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Purkinje cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_8.jpg
Figure 5 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_A_7_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (A549, BJ, fHDF/TERT166, GAMG, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000157168-NRG1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000157168-NRG1
Specifications
- Immunogen
- Recombinant human NRGl-β ECD domain
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human antibody
- Specificity
- Human
- Clone
- 538.24.71
- Applications
- ELISA, Inhib, SPR, FuncS
- Related Disease
- Head and neck squamous carcinoma (HNSCC), Lung cancer, Non- small cell lung cancer (NSCLC)
Applications
- Application Notes
- The antibody was validated for ELISA, Inhibition, Surface Plasmon Resonance, Functional Assay. For details, refer to Published Data.
Target
- Alternative Names
- NRG1; neuregulin 1; GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2; pro-neuregulin-1, membrane-bound isoform; pro-NRG1; glial growth factor; neu differentiation factor; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator)
- Gene ID
- 3084
- UniProt ID
- A6MW56
Related Resources
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1480z | Mouse Anti-NRG1 Recombinant Antibody (clone 9G4) | WB, ELISA, IF | Mouse IgG1 |
| VS-0522-LC114 | Mouse Anti-NRG1 Recombinant Antibody (VS-0522-LC114) | ICC, WB | Mouse IgG2a |
| VS-0522-LC115 | Rat Anti-NRG1 Recombinant Antibody (VS-0522-LC115) | ICC, WB | Rat IgG2b |
| VS-0522-LC116 | Human Anti-NRG1 Recombinant Antibody (VS-0522-LC116) | ICC, WB | Human IgG1 |
| VS-0224-FY18 | Mouse Anti-NRG1 Recombinant Antibody (VS-0224-FY18) | WB, IHC, IP | Mouse IgG2a |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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