Human Anti-NRG1 (clone 526.9) scFv-Fc Chimera
CAT#: VS-0425-FY26
The anti-NRG1 scFv-Fc antibody is a specialized monoclonal antibody designed to specifically bind to both Neuregulin 1α (NRG1α) and Neuregulin 1β (NRG1β) isoforms. Neuregulin 1 (NRG1) is a crucial growth factor involved in the development and maintenance of the nervous system, as well as in various physiological processes. The binding specificity of the anti-NRG1 scFv-Fc antibody makes it an invaluable tool for researchers studying NRG1 signaling pathways.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/1446_D11_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human caudate
Immunohistochemical staining of human caudate shows weak positivity.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_7_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_7_5.jpg
Normal Tissue
Figure 4 Cerebellum
Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Purkinje cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_8.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_A_7_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A549, BJ, fHDF/TERT166, GAMG, U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000157168-NRG1
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Specifications
- Immunogen
- Recombinant human NRGl-β ECD domain
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human NRG1
- Species Reactivity
- Human
- Clone
- 526.9
- Applications
- ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Neuregulin 1; Pro-NRG1; HRGA; SMDF; HGL; GGF; NDF; NRG1 Intronic Transcript 2 (Non-Protein Coding); Heregulin, Alpha (45kD, ERBB2 P185-Activator); Acetylcholine Receptor-Inducing Activity; Pro-Neuregulin-1, Membrane-Bound Isoform
- Gene ID
- 3084
- UniProt ID
- Q02297
- Long Name
- Neuregulin 1
- Sequence Similarities
- Belongs to the neuregulin family.
- Cellular Localization
- Membrane, Nucleus, Secreted, Cell membrane
- Post Translation Modifications
- Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
N- and O-glycosylated.
Extensive glycosylation precedes the proteolytic cleavage.
Glycosylation at Asn120, Asn126, and Asn164
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011542814.2; XP_016868856.2; XP_016868857.1; XP_016868860.2; XP_016868861.2
- Function
- Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors.
Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.
The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart.
Isoform 10 may play a role in motor and sensory neuron development.
Binds to ERBB4.
Binds to ERBB3.
Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4.
Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling.
Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1.
Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons.
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Related Signaling Pathways
ErbB Signaling Pathway
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 526.9"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1480z | Mouse Anti-NRG1 Recombinant Antibody (clone 9G4) | WB, ELISA, IF | Mouse IgG1 |
| VS-0522-LC114 | Mouse Anti-NRG1 Recombinant Antibody (VS-0522-LC114) | ICC, WB | Mouse IgG2a |
| VS-0522-LC115 | Rat Anti-NRG1 Recombinant Antibody (VS-0522-LC115) | ICC, WB | Rat IgG2b |
| VS-0522-LC116 | Human Anti-NRG1 Recombinant Antibody (VS-0522-LC116) | ICC, WB | Human IgG1 |
| VS-0522-LC117 | Rabbit Anti-NRG1 Recombinant Antibody (VS-0522-LC117) | ICC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-579MZ | Mouse Anti-NRG1 Recombinant Antibody (TAB-579MZ) | ELISA, FC, WB | Mouse IgG |
| TAB-580MZ | Mouse Anti-NRG1 Recombinant Antibody (TAB-580MZ) | ELISA, FC, WB | Mouse IgG |
| TAB-581MZ | Mouse Anti-NRG1 Recombinant Antibody (TAB-581MZ) | ELISA, FC, WB | Mouse IgG |
| TAB-582MZ | Mouse Anti-NRG1 Recombinant Antibody (TAB-582MZ) | ELISA, FC, WB | Mouse IgG |
| TAB-579MZ-F(E) | Mouse Anti-NRG1 Recombinant Antibody; Fab Fragment (TAB-579MZ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-583MZ | Human Anti-NRG1 Recombinant Antibody (TAB-583MZ) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| TAB-584MZ | Human Anti-NRG1 Recombinant Antibody (TAB-584MZ) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| TAB-585MZ | Human Anti-NRG1 Recombinant Antibody (TAB-585MZ) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| TAB-583MZ-F(E) | Human Anti-NRG1 Recombinant Antibody; Fab Fragment (TAB-583MZ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
| TAB-584MZ-F(E) | Human Anti-NRG1 Recombinant Antibody; Fab Fragment (TAB-584MZ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-586MZ | Anti-Human NRG1 Recombinant Antibody (538.24) | ELISA, Inhib, SPR | Human antibody |
| TAB-587MZ | Anti-Human NRG1 Recombinant Antibody (538.24.71) | ELISA, Inhib, SPR, FuncS | Human antibody |
| TAB-588MZ | Anti-Human NRG1 Recombinant Antibody (526.9) | ELISA, Inhib | Human antibody |
| TAB-586MZ-F(E) | Anti-Human NRG1 Recombinant Antibody Fab Fragment (538.24) | ELISA | Human antibody |
| TAB-587MZ-F(E) | Anti-Human NRG1 Recombinant Antibody Fab Fragment (538.24.71) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4349 | Hi-Affi™ Recombinant Rabbit Anti-NRG1 Monoclonal Antibody (SI439DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC115 | Recombinant Anti-NRG1 Vesicular Antibody, EV Displayed (VS-0425-YC115) | ELISA, FC, SPR, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4980 | Anti-NRG1 Immunohistochemistry Kit | IHC |
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