Recombinant Anti-SELPLG Vesicular Antibody, EV Displayed (VS-0425-YC186)
CAT#: VS-0425-YC186
The Recombinant Anti-SELPLG Vesicular Antibody, EV Displayed (VS-0425-YC186) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SELPLG-expressed cells or tissues. The SELPLG is a glycoprotein that acts as a counter-receptor for selectins on myeloid cells and T lymphocytes. It is involved in leukocyte trafficking by tethering leukocytes to activated platelets or endothelia expressing selectins, requiring post-translational modifications for high-affinity binding activity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11256/1847_F9_37_cr5abb5d8e30c09_selected.jpg
Normal Tissue
Figure 2 High expression in spleen.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2431/6181_B_8_4_val_selected.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69062/170043_A_9_5.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69062/170043_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, JURKAT, Karpas-707, RPMI-8226, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000110876-SELPLG
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SELPLG
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Selectin P ligand
- Biological Process
- Cell adhesion, Host-virus interaction
- Molecular Function
- Host cell receptor for virus entry, Receptor
- Cellular Localization
- Vesicles
- Introduction
- This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
- Alternative Names
- CD162, PSGL-1
- Gene ID
- 6404
- UniProt ID
- Q14242
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1675z | Mouse Anti-SELPLG Recombinant Antibody (clone 28C8) | FC, ICC, IF, IHC | Mouse IgG1 |
| HPAB-0598-CN | Human Anti-SELPLG Recombinant Antibody (HPAB-0598-CN) | ELISA, FC | Humanized IgG4, κ |
| HPAB-0597-CN | Human Anti-SELPLG Recombinant Antibody (HPAB-0597-CN) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| HPAB-0101-LS | Mouse Anti-SELPLG Recombinant Antibody (HPAB-0101-LS) | ELISA | Mouse IgG1 |
| HPAB-0102-LS | Mouse Anti-SELPLG Recombinant Antibody (HPAB-0102-LS) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-555CL | Human Anti-SELPLG Recombinant Antibody (TAB-555CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-265CT | Anti-Human P-selectin glycoprotein ligand 1 (PSGL-1) Recombinant Antibody | WB, ELISA | Human antibody |
| TAB-265CT-F(E) | Anti-Human P-selectin glycoprotein ligand 1 (PSGL-1) Recombinant Antibody Fab Fragment | WB, ELISA | Human antibody |
| TAB-269CT-F(E) | Anti-Human P-selectin glycoprotein ligand 1 (PSGL-1) Recombinant Antibody Fab Fragment (PSG3) | ELISA, FC | Human antibody |
| TAB-270CT-F(E) | Anti-Human P-selectin glycoprotein ligand 1 (PSGL-1) Recombinant Antibody Fab Fragment (PSG5) | ELISA, FC | Human antibody |
| TAB-271CT-F(E) | Anti-Human P-selectin glycoprotein ligand 1 (PSGL-1) Recombinant Antibody Fab Fragment (PSG6) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1937CQ | Recombinant Mouse Anti-SELPLG Antibody (KPL-1) | BL, WB, IP, IHC-P, IHC-Fr, FC | IgG1, κ |
| NEUT-1938CQ | Recombinant Mouse Anti-SELPLG Antibody (3E2.25.5) | BL, FC, IHC, IHC-Fr, IHC-P, WB | IgG1 |
| NEUT-1939CQ | Recombinant Rat Anti-Selplg Antibody (4RA10) | BL, IHC | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1940CQ | Recombinant Mouse Anti-SELPLG Antibody (CHO131) | BL, CyTOF, FC | IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3204 | Hi-Affi™ Recombinant Rabbit Anti-SELPLG Monoclonal Antibody (DS3204AB) | WB, IP, IHC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0598-CN-S(P) | Human Anti-SELPLG Recombinant Antibody; scFv Fragment (HPAB-0598-CN-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0597-CN-S(P) | Mouse Anti-SELPLG Recombinant Antibody; scFv Fragment (HPAB-0597-CN-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0101-LS-S(P) | Mouse Anti-SELPLG Recombinant Antibody; scFv Fragment (HPAB-0101-LS-S(P)) | ELISA | Mouse scFv |
| HPAB-0102-LS-S(P) | Mouse Anti-SELPLG Recombinant Antibody; scFv Fragment (HPAB-0102-LS-S(P)) | ELISA | Mouse scFv |
| HPAB-0103-LS-S(P) | Mouse Anti-SELPLG Recombinant Antibody; scFv Fragment (HPAB-0103-LS-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0598-CN-F(E) | Human Anti-SELPLG Recombinant Antibody; Fab Fragment (HPAB-0598-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0597-CN-F(E) | Human Anti-SELPLG Recombinant Antibody; Fab Fragment (HPAB-0597-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0101-LS-F(E) | Mouse Anti-SELPLG Recombinant Antibody; Fab Fragment (HPAB-0101-LS-F(E)) | ELISA | Mouse Fab |
| HPAB-0102-LS-F(E) | Mouse Anti-SELPLG Recombinant Antibody; Fab Fragment (HPAB-0102-LS-F(E)) | ELISA | Mouse Fab |
| HPAB-0103-LS-F(E) | Mouse Anti-SELPLG Recombinant Antibody; Fab Fragment (HPAB-0103-LS-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY195 | CytoStream™ Rat Anti-SELPLG Recombinant Antibody (VS-0225-XY195) | FC | Rat IgG1, kappa |
| VS-0225-XY196 | CytoStream™ Rat Anti-SELPLG Recombinant Antibody (clone 4RA10) | FC, Block, IP, WB | Rat IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6439 | Anti-SELPLG Immunohistochemistry Kit | IHC | |
| VS-0525-XY6440 | Anti-Mouse SELPLG Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC162 | Recombinant Anti-SELPLG (AA 50-60 x AA 119-319) Biparatopic Antibody, Tandem scFv | ELISA | Tandem scFv |
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