Recombinant Anti-TLR4 Vesicular Antibody, EV Displayed (VS-0425-YC502)
CAT#: VS-0425-YC502
The Recombinant Anti-TLR4 Vesicular Antibody, EV Displayed (VS-0425-YC502) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TLR4-expressed cells or tissues. TLR4 is a receptor involved in responses to stimuli like pain and metabolism. TLR4 serves as a biomarker for various diseases, including kidney failure and dermatitis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49174/912_G5_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human spleen
Immunohistochemical staining of human spleen shows distinct cytoplasmic positivity in subsets of cells in the red pulp.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49174/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49174/911_G5_4_blue_red_green.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49174/140817_A_8_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in red pulp
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49174/140817_B_7_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Karpas-707, TIME)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Karpas-707, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136869-TLR4
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TLR4
- Host Animal
- Rat
- Antibody Isotype
- IgG
- Species Reactivity
- Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Toll like receptor 4
- Biological Process
- Immunity, Inflammatory response, Innate immunity
- Molecular Function
- Receptor
- Cellular Localization
- Golgi apparatus, Plasma membrane
- Introduction
- Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular response to mechanical stimulus; detection of stimulus involved in sensory perception of pain; and regulation of macromolecule metabolic process. Located in cell surface. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including kidney failure (multiple); liver disease (multiple); pancreatitis (multiple); perinatal necrotizing enterocolitis; and pulpitis. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4).
- Gene ID
- 29260
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Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway
Related Diseases
Rheumatoid Arthritis
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| PFBL-722 | Human Anti-TLR4 Recombinant Antibody; Fab Fragment (PFBL-722) | Neut | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| FN-223CQ | Mouse Anti-TLR4 Recombinant Antibody (VMC213) | FC, FuncS | Mouse IgG1 |
| HPAB-AP199-YC | Human Anti-TLR4 Recombinant Antibody (HPAB-AP199-YC) | FC, ELISA, Inhib | Human IgG |
| HPAB-AP200-YC | Human Anti-TLR4 Recombinant Antibody (HPAB-AP200-YC) | FC, ELISA, Inhib | Human IgG |
| HPAB-AP201-YC | Human Anti-TLR4 Recombinant Antibody (HPAB-AP201-YC) | ELISA, FC, Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-181 | Human Anti-TLR4 Recombinant Antibody (PABX-181) | WB, ELISA, FuncS | Human IgG |
| PABX-181-F (E) | Human Anti-TLR4 Recombinant Antibody; Fab Fragment (PABX-181-F (E)) | WB, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-181-S (P) | Human Anti-TLR4 Recombinant Antibody; scFv Fragment (PABX-181-S (P)) | WB, ELISA, FuncS | Human scFv |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| NEUT-2038CQ | Mouse Anti-TLR4 Recombinant Antibody (clone CBL961) | FC, ICC, IF, IP, Neut | Mouse IgG2a, κ |
| NEUT-2039CQ | Mouse Anti-TLR4 Recombinant Antibody (clone HTA125) | ICC, IP, FC, Neut | Mouse IgG2a |
| NEUT-2040CQ | Mouse Anti-TLR4 Recombinant Antibody (NEUT-2040CQ) | Neut | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP199-YC-S(P) | Human Anti-TLR4 Recombinant Antibody; scFv Fragment (HPAB-AP199-YC-S(P)) | ELISA, FC, Inhib | Human scFv |
| HPAB-AP200-YC-S(P) | Human Anti-TLR4 Recombinant Antibody; scFv Fragment (HPAB-AP200-YC-S(P)) | ELISA, FC, Inhib | Human scFv |
| HPAB-AP201-YC-S(P) | Human Anti-TLR4 Recombinant Antibody; scFv Fragment (HPAB-AP201-YC-S(P)) | ELISA, FC, Inhib | Human scFv |
| HPAB-AP202-YC-S(P) | Human Anti-TLR4 Recombinant Antibody; scFv Fragment (HPAB-AP202-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-0678YY-S(P) | Human Anti-TLR4 Recombinant Antibody (clone CBT111YJ); scFv Fragment | ELISA, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY255 | AbPlus™ Anti-TLR4 Magnetic Beads (HTA125) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY505 | Mouse Anti-NHP TLR4 Recombinant Antibody (clone HTA125) | FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1162 | CytoStream™ Rabbit Anti-TLR4 Polyclonal Antibody (VS13-YC1162) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY30 | Human Anti-TLR4 scFv-Fc Chimera (VS-0425-FY30) | FC, ELISA, Neut | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7306 | Anti-TLR4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7307 | Anti-Mouse TLR4 Immunohistochemistry Kit | IHC |
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