AbPlus™ Anti-TLR4 Magnetic Beads (HTA125)
CAT#: VS-0424-XY255
The AbPlus Anti-TLR4 Magnetic Beads (HTA125) is an innovative affinity resin which is bound with anti-TLR4 specific antibody (HTA125). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of TLR4 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49174/912_G5_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human spleen
Immunohistochemical staining of human spleen shows distinct cytoplasmic positivity in subsets of cells in the red pulp.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49174/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49174/911_G5_4_blue_red_green.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49174/140817_A_8_8.jpg
Normal Tissue
Figure 5 Spleen
Cells in red pulp
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49174/140817_B_7_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Karpas-707, TIME)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Karpas-707, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136869-TLR4
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-TLR4 specific antibody (HTA125)
- Target
- TLR4
- Immunogen
- Recombinant human TLR4
- Target Species
- Human
- Antibody Clone
- HTA125
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- TLR4; toll-like receptor 4; TOLL; CD284; TLR-4; ARMD10; hToll; homolog of Drosophila toll
- Gene ID
- 7099
- UniProt ID
- O00206
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Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway
Related Diseases
Rheumatoid Arthritis
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-AP201-YC-S(P) | Human Anti-TLR4 Recombinant Antibody; scFv Fragment (HPAB-AP201-YC-S(P)) | ELISA, FC, Inhib | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-181 | Human Anti-TLR4 Recombinant Antibody (PABX-181) | WB, ELISA, FuncS | Human IgG |
| PABX-181-F (E) | Human Anti-TLR4 Recombinant Antibody; Fab Fragment (PABX-181-F (E)) | WB, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
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| PABX-181-S (P) | Human Anti-TLR4 Recombinant Antibody; scFv Fragment (PABX-181-S (P)) | WB, ELISA, FuncS | Human scFv |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0318CQ-F(E) | Rat Anti-Tlr4 Recombinant Antibody Fab Fragment (HPAB-0318CQ-F(E)) | FC, IP, Apop | Rat Fab |
| HPAB-AP199-YC-F(E) | Human Anti-TLR4 Recombinant Antibody; Fab Fragment (HPAB-AP199-YC-F(E)) | ELISA, FC, Inhib | Human Fab |
| HPAB-AP200-YC-F(E) | Human Anti-TLR4 Recombinant Antibody; Fab Fragment (HPAB-AP200-YC-F(E)) | ELISA, FC, Inhib | Human Fab |
| HPAB-AP201-YC-F(E) | Human Anti-TLR4 Recombinant Antibody; Fab Fragment (HPAB-AP201-YC-F(E)) | ELISA, FC, Inhib | Human Fab |
| HPAB-AP202-YC-F(E) | Human Anti-TLR4 Recombinant Antibody; Fab Fragment (HPAB-AP202-YC-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7306 | Anti-TLR4 Immunohistochemistry Kit | IHC | |
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