Recombinant Rabbit Anti-TREM2 Detection Antibody (clone R76-7H-6) (CAT#: VS3-WK1945)
This antibody is a rabbit recombinant antibody against human TREM2. It was developed by immunization of rabbit with recombinant human TREM2 protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. R49-8Q-2 and R76-7H-6 were identified as antibody pair for sandwich ELISA. As a detection antibody, the clone R76-7H-6 can be used in ELISA analysis to identify human TREM2.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human gallbladder
(Immunohistochemical staining of human gallbladder shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_6_4_selected.jpg
(Immunohistochemical staining of human gallbladder shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_6_4_selected.jpg
Figure 2 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_B_8_5.jpg
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_B_8_5.jpg
Figure 3 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_7_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_7_5.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_6_6.jpg
Figure 5 RNA cell line category: Group enriched (hTCEpi, THP-1)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000095970-TREM2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000095970-TREM2
Specifications
- Immunogen
- Recombinant human TREM2 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human TREM2
- Species Reactivity
- Human
- Clone
- R76-7H-6
- Applications
- ELISA
- Conjugate
- Unconjugated
- Related Disease
- Alzheimer's disease
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Triggering Receptor Expressed On Myeloid Cells 2; Triggering Receptor Expressed On Myeloid Cells 2a; Triggering Receptor Expressed On Monocytes 2; TREM-2; Trem2a; Trem2b; Trem2c
- Gene ID
- 54209
- UniProt ID
- Q9NZC2
- Long Name
- Triggering Receptor Expressed On Myeloid Cells 2
- Cellular Localization
- Cell membrane; Secreted
- Post Translation Modifications
- Undergoes ectodomain shedding through proteolytic cleavage by ADAM10 and ADAM17 to produce a transmembrane segment, the TREM2 C-terminal fragment (TREM2-CTF), which is subsequently cleaved by gamma-secretase.
- Protein Refseq
- NP_001258750.1; NP_061838.1
- Function
- Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding.
Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.
Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
ScFv Antibody Products
IgG Antibody Products
Fab Antibody Products
Agonistic Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-168CQ | Human Anti-TREM2 Recombinant Antibody (TAB-168CQ) | ELISA, FC, WB, FuncS | Human IgG |
| TAB-169CQ | Human Anti-TREM2 Recombinant Antibody (TAB-169CQ) | ELISA, FC, WB, FuncS | Human IgG |
| TAB-168CQ-S(P) | Human Anti-TREM2 Recombinant Antibody; scFv Fragment (TAB-168CQ-S(P)) | ELISA, FC, WB, FuncS | Human scFv |
| TAB-168CQ-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (TAB-168CQ-F(E)) | ELISA, FC, WB, FuncS | Human Fab |
| TAB-169CQ-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (TAB-169CQ-F(E)) | ELISA, FC, WB, FuncS | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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