Disease related genes, Human disease related genes
Membrane, Secreted (different isoforms)
Cell type enriched (Hofbauer cells)
Immune cell enhanced (plasmacytoid DC)
Group enriched (hTCEpi, THP-1)
Monomer (PubMed:27995897). After ectodomain shedding, the extracellular domain oligomerizes, which is enhanced and stabilized by binding of phosphatidylserine (PubMed:29794134). Interacts with TYROBP/DAP12 (PubMed:11602640, PubMed:25957402). Interaction with TYROBP is required for stabilization of the TREM2 C-terminal fragment (TREM2-CTF) which is produced by proteolytic processing (PubMed:25957402).
Receptor
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For Research Use Only. Not For Clinical Use.