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TREM2

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Anti-TREM2 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class

Disease related genes, Human disease related genes

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Hofbauer cells)

Immune cell specificity

Immune cell enhanced (plasmacytoid DC)

Cell line specificity

Group enriched (hTCEpi, THP-1)

Interaction

Monomer (PubMed:27995897). After ectodomain shedding, the extracellular domain oligomerizes, which is enhanced and stabilized by binding of phosphatidylserine (PubMed:29794134). Interacts with TYROBP/DAP12 (PubMed:11602640, PubMed:25957402). Interaction with TYROBP is required for stabilization of the TREM2 C-terminal fragment (TREM2-CTF) which is produced by proteolytic processing (PubMed:25957402).

Molecular function

Receptor

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