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    TREM2

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    For Research Use Only. Not For Clinical Use.


    This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
    Protein class

    Disease related genes, Human disease related genes

    Predicted location

    Membrane, Secreted (different isoforms)

    Single cell type specificity

    Cell type enriched (Hofbauer cells)

    Immune cell specificity

    Immune cell enhanced (plasmacytoid DC)

    Cell line specificity

    Group enriched (hTCEpi, THP-1)

    Interaction

    Monomer (PubMed:27995897). After ectodomain shedding, the extracellular domain oligomerizes, which is enhanced and stabilized by binding of phosphatidylserine (PubMed:29794134). Interacts with TYROBP/DAP12 (PubMed:11602640, PubMed:25957402). Interaction with TYROBP is required for stabilization of the TREM2 C-terminal fragment (TREM2-CTF) which is produced by proteolytic processing (PubMed:25957402).

    Molecular function

    Receptor

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