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Anti-TREM2 Recombinant Antibody Products

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Anti-TREM2 Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is a global leader in recombinant antibody development, proudly offering a premium selection of anti-TREM2 recombinant antibody products. Engineered with precision and validated for superior performance, these antibodies empower researchers worldwide to accelerate breakthroughs in neurodegenerative disease mechanisms and therapeutic development, ensuring reliable and reproducible results for critical studies.

TREM2: A Key Target for Neurodegenerative Diseases

TREM2 (Triggering Receptor Expressed on Myeloid cells 2) is a transmembrane glycoprotein primarily expressed on microglia and other myeloid cells in the central nervous system. Extensive research highlights its critical role in microglial function, including phagocytosis, inflammation regulation, and cell survival. Recent studies increasingly position TREM2 as a crucial player in the pathogenesis and progression of various neurodegenerative disorders, making it a compelling target for understanding disease mechanisms and developing novel therapeutic strategies.

Alternative Names

Triggering receptor expressed on myeloid cells 2; TREM-2; Trem2a; Trem2b; Trem2c; PLOSL2.

Background

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012].

Protein class

Disease related genes, Human disease related genes

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Hofbauer cells)

Immune cell specificity

Immune cell enhanced (plasmacytoid DC)

Cell line specificity

Group enriched (hTCEpi, THP-1)

Interaction

Monomer (PubMed:27995897). After ectodomain shedding, the extracellular domain oligomerizes, which is enhanced and stabilized by binding of phosphatidylserine (PubMed:29794134). Interacts with TYROBP/DAP12 (PubMed:11602640, PubMed:25957402). Interaction with TYROBP is required for stabilization of the TREM2 C-terminal fragment (TREM2-CTF) which is produced by proteolytic processing (PubMed:25957402).

Molecular function

Receptor

More Types Infomation

Anti-TREM2 rAb Products

Our anti-TREM2 recombinant antibody products are meticulously developed to offer unparalleled specificity and affinity. Utilizing advanced recombinant technology, these antibodies ensure lot-to-lot consistency and minimal batch variation, providing researchers with highly reliable tools. Their exceptional purity and precise binding capabilities significantly enhance experimental accuracy across diverse research applications, from basic discovery to preclinical development.

Table 1. Featured anti-TREM2 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
HPAB-3349LY-F(E) Human Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-3349LY-F(E)) Human Humanized Fab FC, WB, IP, ELISA, IHC
HPAB-3354LY-F(E) Human Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-3354LY-F(E)) Human Humanized Fab FC, WB, IP, ELISA, IHC
HPAB-0155-CN Mouse Anti-TREM2 Recombinant Antibody (HPAB-0155-CN) Human Mouse IgG1 WB, ELISA, FC, IHC, IF, IP
HPAB-0154-CN Mouse Anti-TREM2 Recombinant Antibody (HPAB-0154-CN) Human Mouse IgG1 WB, ELISA, FC, IHC, IF, IP
TAB-168CQ Human Anti-TREM2 Recombinant Antibody (TAB-168CQ) Human, Mouse Human IgG ELISA, FC, WB, FuncS

Creative Quality Control

Creative Biolabs implements a rigorous, multi-faceted quality control process for all anti-TREM2 recombinant antibodies. Each batch undergoes comprehensive validation to verify specificity, sensitivity, and functionality. This stringent quality assurance guarantees that every product meets the highest industry standards for purity, activity, and consistency.

Fig.1 SEC-HPLC analysis. (Creative Biolabs Original)Fig.1 SEC-HPLC analysis of anti-TREM2 antibody
(Cat# HPAB-0155-CN, Creative Biolabs).

Fig.2 WB analysis. (Creative Biolabs Original)Fig.2 WB analysis of anti-TREM2 antibody
(Cat# HPAB-0155-CN, Creative Biolabs).

Fig.3 DB analysis. (Creative Biolabs Original)Fig.3 DB analysis of anti-TREM2 antibody
(Cat# HPAB-0155-CN, Creative Biolabs).

Fig.4 ELISA analysis. (Creative Biolabs Original)Fig.4 ELISA analysis of anti-TREM2 antibody
(Cat# HPAB-0155-CN, Creative Biolabs).

Fig.5 HPLC analysis. (Creative Biolabs Original)Fig.5 HPLC analysis of anti-TREM2 antibody
(Cat# HPAB-0154-CN, Creative Biolabs).

Fig.6 ELISA analysis. (Creative Biolabs Original)Fig.6 ELISA analysis of anti-TREM2 antibody
(Cat# TAB-168CQ, Creative Biolabs).

Customer Reviews

Excellent
Em***y Ch*n
Human Anti-TREM2 Recombinant Antibody (TAB-168CQ) (TAB-168CQ)
The anti-TREM2 recombinant antibody from Creative Biolabs exceeded my expectations. Its performance in my Western Blot assays was consistently sharp and reliable, providing clear and strong signals. This product has significantly streamlined my research workflow, allowing for much faster and more accurate data collection. I highly recommend it for its exceptional quality.
15/Nov/2024
Excellent
Da***d L*e
Mouse Anti-TREM2 Agonistic Antibody (clone al002c) (VS-0724-XY58)
We've incorporated Creative Biolabs' anti-TREM2 antibody into our cellular functional studies, and the results have been outstanding. The antibody demonstrated excellent binding kinetics and specificity in our in vitro assays, proving invaluable for our microglial activation experiments. The consistency between batches is also a huge plus, ensuring reproducibility across our projects.
11/May/2025
Excellent
Sa***h Mi**er
Mouse Anti-TREM2 Recombinant Antibody (HPAB-0155-CN) (HPAB-0155-CN)
The technical support from Creative Biolabs was as impressive as their anti-TREM2 recombinant antibody. It performed flawlessly in our IHC applications, yielding clean and specific staining with minimal background. This antibody has become a staple in our neuroinflammation research, consistently delivering the high-quality data we need for our therapeutic development programs
1/Jun/2025

rAb Production

The production of our anti-TREM2 recombinant antibodies leverages state-of-the-art mammalian cell expression systems. This advanced platform ensures high-yield production of full-length, glycosylated antibodies, critical for native conformation and optimal biological activity. Our proprietary purification techniques further guarantee exceptionally high purity, free from host cell contaminants.

Featured Anti-TREM2 Recombinant Antibody Production PlatformsFig.7 Milligram-scale. (Creative Biolabs Original)
Fig.7 Milligram-scale anti-TREM2 recombinant antibody production.

Fig.8 Gram-scale. (Creative Biolabs Original)Fig.8 Gram-scale anti-TREM2 recombinant antibody production.

rAb Modalities

Creative Biolabs' anti-TREM2 recombinant antibodies are available in various formats and conjugates, suitable for a wide array of applications including ELISA, Western Blot, IHC, ICC, and flow cytometry.

Fig.9 TREM2 antibody production and modalities. (Creative Biolabs Original)Fig.9 Full-length anti-TREM2 recombinant antibody production and modalities.

TREM2-Targeted Drug Information

Table 2. Public drug targeting TREM2.

Research phase Company Classification Indications Details
Vigil Neuroscience (Originator) Phase II Agonist Antibodies
Human Monoclonal Antibodies
Leukoencephalopathy
AbbVie
Alector (Originator)
Phase II Agonist Antibodies
Humanized Monoclonal Antibodies
Dementia, Alzheimer type
Pionyr Immunotherapeutics (Originator) Phase I Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer, breast
Cancer, colorectal
Cancer, kidney
Cancer, lung
Cancer, ovary
Cancer, solid tumor
Denali (Denali Therapeutics)
Denali Therapeutics (Originator)
Takeda
Discontinued Agonist Antibodies
Antibodies
Dementia, Alzheimer type
Neurodegeneration
Lilly (Originator) Preclinical Adeno-Associated Viral (AAV) Vectors
Gene Therapy
Leukoencephalopathy
University of Texas Health Science Center at Houston (Originator) Preclinical Agonist Antibodies
Bispecific Antibody Fusions
Fusion Proteins
Polypeptides, from 41 AA
Single-Chain V-Domain Antibody Fragment (scFv)
Dementia, Alzheimer type
Prevail Therapeutics (Originator) Preclinical Adeno-Associated Viral (AAV) Vectors
Gene Therapy
Dementia, Alzheimer type
University of Texas Health Science Center at Houston (Originator) Preclinical Bispecific Antibodies
Bispecific Antibody Fusions
Fusion Proteins
Polypeptides, from 41 AA
Single-Chain V-Domain Antibody Fragment (scFv)
Single-Domain Antibodies
Dementia, Alzheimer type
Cognyxx (Originator) Preclinical Agonist Antibodies
Monoclonal Antibodies
Neurodegeneration
Washington University (Originator) Preclinical Cancer Immunotherapy
Murine Monoclonal Antibodies
Cancer
Amgen (Originator)
Washington University (Originator)
Preclinical Agonist Antibodies
Chimeric Monoclonal Antibodies
Dementia, Alzheimer type
Amgen (Originator)
Washington University (Originator)
Preclinical Agonist Antibodies
Human Monoclonal Antibodies
Dementia, Alzheimer type

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

At Creative Biolabs, we are committed to empowering your scientific endeavors with cutting-edge reagents. Our anti-TREM2 recombinant antibody products represent our dedication to quality and innovation. Explore how our solutions can advance your research by reaching out to our expert team today. We look forward to collaborating on your next breakthrough.

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