Anti-MUC16 (clone 3A5)-vc-MMAE ADC (CAT#: ADC-046CL)

• Antibody Overview
• Std Hu 3A5 is the parent Chimeric Anti-MUC16 Antibody called 3A5

• Clone
• 3A5

• Linker
• VC (valine-citrulline)

• Linker Class/Description
• Class: Enzymatically cleavable linkers-Peptide linkers
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include mucinous ovarian cystadenoma and pleural cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

• Alternative Names
• MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;

• Gene ID
• 94025

• UniProt ID
• B3KY81

• ADC-044CL
• Anti-MUC16 (clone 3A5)-MC-vc-PAB-MMAE ADC

• ADC-045CL
• Anti-MUC16 (clone 3A5)-MC-vc-PAB-MMAE ADC

• ADC-047CL
• Anti-MUC16 (clone 3A5)-vc-MMAE ADC

• ADC-188CL
• Anti-MUC16 (clone 3A5)-BMPEO-DM1 ADC

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