Anti-MUC16 (clone 3A5)-BMPEO-DM1 ADC

Name: Anti-MUC16 (clone 3A5)-BMPEO-DM1 ADC
SKU: ADC-188CL
Rating: 5 (1 reviews)

CAT#: ADC-188CL

This ADC product is composed of an anti-MUC16 antibody (clone 3A5) conjugated via BMPEO linker to DM1(thio-3A5 (HC A121C)-BMPEO-DMl). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.

Gene Expression

Normal Tissue Figure 1 Cervix

Glandular cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65600/166228_B_7_3.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (A-431, HeLa)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16

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Specifications

Antibody Overview
Anti-MUC16 Antibody, Thio-3A5 (HC A121C)

Clone
3A5

Antibody Conjugation
Thio

Linker
BMPEO (bis-maleimido-trioxyethylene glycol)

Drug
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

Drug Class/Description
Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

Introduction
MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include mucinous ovarian cystadenoma and pleural cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Alternative Names
MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;

Gene ID
94025

UniProt ID
B3KY81

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Datasheet

Datasheet - ADC-188CL.pdf

MSDS

MSDS - ADC-188CL.pdf

COA

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