Anti-MUC16 (clone 3A5)-BMPEO-DM1 ADC (CAT#: ADC-188CL)
This ADC product is composed of an anti-MUC16 antibody (clone 3A5) conjugated via BMPEO linker to DM1(thio-3A5 (HC A121C)-BMPEO-DMl). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cervix
(Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65600/166228_B_7_3.jpg
(Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65600/166228_B_7_3.jpg
Figure 2 RNA cell line category: Group enriched (A-431, HeLa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16
Figure 2 RNA cell line category: Group enriched (A-431, HeLa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16
Specifications
- Antibody Overview
- Anti-MUC16 Antibody, Thio-3A5 (HC A121C)
- Clone
- 3A5
- Antibody Conjugation
- Thio
- Linker
- BMPEO (bis-maleimido-trioxyethylene glycol)
- Drug
- DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include mucinous ovarian cystadenoma and pleural cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.
- Alternative Names
- MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;
- Gene ID
- 94025
- UniProt ID
- B3KY81
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H63 | Humanized Anti-MUC16 Recombinant V-kappa Antibody (clone Sofituzumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | Humanized IgG1, κ |
| TAB-1397CL-S(P) | Human Anti-MUC16 Recombinant Antibody; scFv Fragment (TAB-1397CL-S(P)) | FuncS | Humanized scFv |
| TAB-1399CL-S(P) | Human Anti-MUC16 Recombinant Antibody; scFv Fragment (TAB-1399CL-S(P)) | FuncS | Humanized scFv |
| TAB-1397CL-F(E) | Human Anti-MUC16 Recombinant Antibody; Fab Fragment (TAB-1397CL-F(E)) | FuncS | Humanized Fab |
| TAB-1399CL-F(E) | Human Anti-MUC16 Recombinant Antibody; Fab Fragment (TAB-1399CL-F(E)) | FuncS | Humanized Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-043 | Anti-Human MUC16 Recombinant Antibody F(ab')2 Fragment( Igovomab) | ELISA, FC, IP, FuncS, IF, Neut, IHC | F(ab')2 - G1 |
| TAB-1401CL-S(P) | Anti-Human MUC16 Recombinant Antibody scFv Fragment (OC125) | IF, IHC, IP, FC | |
| TAB-1402CL-S(P) | Anti-Human MUC16 Recombinant Antibody scFv Fragment (VK-8) | IF, FC | |
| TAB-1401CL-F(E) | Anti-Human MUC16 Recombinant Antibody Fab Fragment (OC125) | IF, IHC, IP, FC | |
| TAB-1402CL-F(E) | Anti-Human MUC16 Recombinant Antibody Fab Fragment (VK-8) | IF, FC |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1398CL | Human Anti-MUC16 Recombinant Antibody (TAB-1398CL) | FuncS | Chimeric (mouse/human) IgG |
| TAB-1400CL | Human Anti-MUC16 Recombinant Antibody (TAB-1400CL) | FuncS | Chimeric (mouse/human) IgG |
| TAB-1398CL-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (TAB-1398CL-S(P)) | FuncS | Mouse scFv |
| TAB-1398CL-F(E) | Human Anti-MUC16 Recombinant Antibody; Fab Fragment (TAB-1398CL-F(E)) | FuncS | Chimeric (mouse/human) Fab |
| TAB-1400CL-F(E) | Human Anti-MUC16 Recombinant Antibody; Fab Fragment (TAB-1400CL-F(E)) | FuncS | Chimeric (mouse/human) Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2321 | Hi-Affi™ Recombinant Rabbit Anti-MUC16 Monoclonal Antibody (DS2321AB) | ICC, IHC-P, WB | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0310-YC | Mouse Anti-MUC16 Recombinant Antibody (HPAB-0310-YC) | ELISA, FC, IHC, FuncS | Mouse IgG |
| FAMAB-0043YC | Mouse Anti-MUC16 Recombinant Antibody (clone 196-14) | FuncS | Mouse IgG1, κ |
| FAMAB-0044YC | Human Anti-MUC16 Recombinant Antibody (clone ch196-14) | FuncS | Chimeric (mouse/human) IgG |
| HPAB-1114LY | Mouse Anti-MUC16 Recombinant Antibody (HPAB-1114LY) | ELISA | Mouse IgG |
| ZG-0475U | Rabbit Anti-MUC16 Recombinant Antibody (clone 10E9) | ELISA, IHC | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0310-YC-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-0310-YC-S(P)) | ELISA, FC, IHC, FuncS | Mouse scFv |
| HPAB-1114LY-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-1114LY-S(P)) | ELISA | Mouse scfv |
| HPAB-1115LY-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-1115LY-S(P)) | ELISA | Mouse scfv |
| HPAB-1116LY-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-1116LY-S(P)) | ELISA | Mouse scfv |
| HPAB-N0185-YC-S(P) | Human Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-N0185-YC-S(P)) | FuncS | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0310-YC-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-0310-YC-F(E)) | ELISA, FC, IHC, FuncS | Mouse Fab |
| FAMAB-0043-YC-F(E) | Mouse Anti-MUC16 Recombinant Antibody (clone 196-14); Fab Fragment | FuncS | Mouse Fab |
| FAMAB-0044-YC-F(E) | Human Anti-MUC16 Recombinant Antibody (clone ch196-14); Fab Fragment | FuncS | Human Fab |
| HPAB-0120LY-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-0120LY-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
| HPAB-0121LY-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-0121LY-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-114 | Afuco™ Anti-MUC16 ADCC Recombinant Antibody (Abagovomab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| AFC-TAB-H63 | Afuco™ Anti-MUC16 ADCC Recombinant Antibody (Sofituzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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