Anti-MUC16 (clone 3A5)-BMPEO-DM1 ADC (CAT#: ADC-188CL)

• Antibody Overview
• Anti-MUC16 Antibody, Thio-3A5 (HC A121C)

• Clone
• 3A5

• Antibody Conjugation
• Thio

• Linker
• BMPEO (bis-maleimido-trioxyethylene glycol)

• Drug
• DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

• Introduction
• MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include mucinous ovarian cystadenoma and pleural cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

• Alternative Names
• MUC16; mucin 16, cell surface associated; CA125; mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;

• Gene ID
• 94025

• UniProt ID
• B3KY81

• ADC-044CL
• Anti-MUC16 (clone 3A5)-MC-vc-PAB-MMAE ADC

• ADC-045CL
• Anti-MUC16 (clone 3A5)-MC-vc-PAB-MMAE ADC

• ADC-046CL
• Anti-MUC16 (clone 3A5)-vc-MMAE ADC

• ADC-047CL
• Anti-MUC16 (clone 3A5)-vc-MMAE ADC

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