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For Research Use Only. Not For Clinical Use.
Cancer-related genes, CD markers, Plasma proteins, Transporters
Membrane, Secreted (different isoforms)
Cell type enhanced (Oligodendrocytes, Alveolar cells type 1, Oligodendrocyte precursor cells, Respiratory ciliated cells)
Immune cell enhanced (myeloid DC)
Cell line enhanced (hTERT-HME1, U-138 MG)
Homodimer (PubMed:7760007, PubMed:16352806, PubMed:15048703, PubMed:26146185). Interacts (via extracellular domain) with CD6 (via extracellular domain) (PubMed:7760007, PubMed:8823162, PubMed:15048703, PubMed:16914752, PubMed:24945728, PubMed:26146185). Homodimerization and interaction with CD6 involve the same region and cannot occur simultaneously. The affinity for CD6 is much higher than the affinity for self-association (PubMed:15048703). Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3 (PubMed:24945728). Interaction with LGALS1 or LGALS3 inhibits interaction with CD6 (PubMed:24945728).