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ALCAM
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Protein class
Cancer-related genes, CD markers, Plasma proteins, Transporters
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Alveolar cells type 1, Oligodendrocyte precursor cells, Respiratory ciliated cells)
Immune cell specificity
Immune cell enhanced (myeloid DC)
Cell line specificity
Cell line enhanced (hTERT-HME1, U-138 MG)
Interaction
Homodimer (PubMed:7760007, PubMed:16352806, PubMed:15048703, PubMed:26146185). Interacts (via extracellular domain) with CD6 (via extracellular domain) (PubMed:7760007, PubMed:8823162, PubMed:15048703, PubMed:16914752, PubMed:24945728, PubMed:26146185). Homodimerization and interaction with CD6 involve the same region and cannot occur simultaneously. The affinity for CD6 is much higher than the affinity for self-association (PubMed:15048703). Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3 (PubMed:24945728). Interaction with LGALS1 or LGALS3 inhibits interaction with CD6 (PubMed:24945728).
More Types Infomation
- APC-H-2Kd/Human CD166 (SLNVSAISI) MHC Tetramer (MHC-CN0273)
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- Class: Class I
- Antigen: CD166
- Antigen Species: Human
- Peptide: SLNVSAISI
- Conjugate: APC
- PE-H-2Kd/Human CD166 (SLNVSAISI) MHC Tetramer (MHC-CN0274)
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- Class: Class I
- Antigen: CD166
- Antigen Species: Human
- Peptide: SLNVSAISI
- Conjugate: PE
- Mouse Anti-ALCAM Recombinant Antibody (clone AZN-L50) (MOR-0012-FY)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, FuncS, IF, IP, WB
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: FC
- Mouse Anti-ALCAM Recombinant Antibody (clone 4G9C23) (MOB-0457CT)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC, IP
- Mouse Anti-ALCAM Recombinant Antibody (clone CBL314) (NEUT-019CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, Block
- Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0959-FY-S(P)) (HPAB-0959-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: IHC
- Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0958-FY-S(P)) (HPAB-0958-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: IHC
- Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0957-FY-S(P)) (HPAB-0957-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: IHC
- Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0955-FY-S(P)) (HPAB-0955-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: IHC
- Human Anti-ALCAM Recombinant Antibody (HPAB-0959-FY) (HPAB-0959-FY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: IHC
- Human Anti-ALCAM Recombinant Antibody (HPAB-0958-FY) (HPAB-0958-FY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: IHC, WB
- Human Anti-ALCAM Recombinant Antibody (HPAB-0957-FY) (HPAB-0957-FY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: IHC
- Human Anti-ALCAM Recombinant Antibody (HPAB-0955-FY) (HPAB-0955-FY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: IHC
- Human Anti-ALCAM Recombinant Antibody (HPAB-0954-FY) (HPAB-0954-FY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: IHC
- Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0954-FY-S(P)) (HPAB-0954-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: IHC
- Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0953-FY-S(P)) (HPAB-0953-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: IHC
- Human Anti-ALCAM Recombinant Antibody; scFv Fragment (HPAB-0952-FY-S(P)) (HPAB-0952-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: IHC
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