BAD

Recombinant Antibody Products Functional Antibody Products Formats

Anti-BAD Recombinant Antibody Products

Rabbit Anti-BAD Recombinant Antibody (clone CBACN-058) (MRO-0149-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
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Rabbit Anti-BAD Polyclonal Antibody (MRO-1677-CN) (MRO-1677-CN)
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IF, IHC, FC
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Mouse Anti-BAD Recombinant Antibody (clone 27AT381) (VS3-QX100)
- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB
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Mouse Anti-BAD Recombinant Antibody (clone 1B1) (VS3-XY115)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
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Rat Anti-Bad Agonistic Antibody (VS-0724-XY2) (VS-0724-XY2)
- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: WB, ICC
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Mouse Anti-BAD Agonistic Antibody (VS-0724-XY3) (VS-0724-XY3)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC
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Mouse Anti-BAD Recombinant Antibody (clone 2H4) (VS3-XY116)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, IF, IHC
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Mouse Anti-BAD Recombinant Antibody (clone 1G5B3) (VS3-XY117)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
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Rabbit Anti-BAD Recombinant Antibody (VS3-WK1090) (VS3-WK1090)
- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
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Recombinant Rabbit Anti-BAD Antibody (clone R07-1B6) (VS3-FY131)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-F, IHC-P, ICC, IF, IP
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Rabbit Anti-BAD (pS112) Recombinant Antibody (clone R07-7Y9) (VS3-WK2175)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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Mouse Anti-BAD Agonistic Antibody (VS-0724-XY1) (VS-0724-XY1)
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IHC, ICC
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Rabbit Anti-NHP BAD Recombinant Antibody (VS-1024-XY46) (VS-1024-XY46)
- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Rabbit IgG
- Application: WB, IF
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Chicken Anti-BAD Polyclonal IgY (BRD-0064MZ)
- Species Reactivity: Human, Rat
- Type: Chicken antibody
- Application: WB
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Hi-Affi™ Rabbit Anti-BAD Recombinant Antibody (clone DS317AB) (MOR-0317)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IP
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Protein class

Cancer-related genes, RAS pathway related proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity). Interacts with AKT1 and PIM3. Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BAD with BCL2 (By similarity). Interacts with HIF3A (via C-terminus domain); the interaction reduces the binding between BAD and BAX (By similarity). Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (PubMed:16509771).

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Related Signaling Pathways

cAMP Signaling Pathway