Anti-BAD Products

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For Research Use Only. Not For Clinical Use.

BAD is a potent pro-apoptotic member of the BCL2 family and serves as a sensor of cell survival signals. Creative Biolabs' top-notch anti-BAD recombinant antibodies, including phospho-specific variants, are a perfect tool for your studies on the PI3K/AKT signaling pathway and the regulation of the mitochondrial pathway of apoptosis.

BAD: A Sentinel of the Mitochondrial Apoptosis Pathway

BCL2 Associated Death Promoter (BAD) is a pro-apoptotic BH3-only member of the BCL2 family. BAD promotes apoptosis in its dephosphorylated state by binding and sequestering anti-apoptotic proteins, such as BCL2 and BCL-xL, and thereby disinhibits the function of the pro-apoptotic BAX and BAK proteins which permeabilize the outer mitochondrial membrane. BAD is under strict regulatory control by phosphorylation. Cell survival signals, mediated by PI3K and subsequent activation of AKT and other kinases, phosphorylate BAD at specific serine residues. Phosphorylated BAD, in turn, provides a binding site for 14-3-3 proteins, which sequester BAD to the cytoplasm and prevent it from exerting its pro-apoptotic function.

Alternative Names

BBC2; BCL2L8

Background

The protein encoded by this gene is a member of the BCL-2 family. The BCL-2 family members are regulators of programmed cell death. It positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Phosphorylation regulates proapoptotic activity of this protein. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Anti-BAD rAb Products

Creative Biolabs' anti-BAD recombinant antibodies are some of the most highly specific and high-performing antibodies for research on the PI3K/AKT signaling pathway and regulation of apoptosis. We provide a full suite of BAD antibodies, including highly specific antibodies to total BAD, as well as phospho-specific antibodies against key phosphorylation sites (e.g., Ser112, Ser136). These tools are perfect for using Western Blot to track the activity of the PI3K/AKT survival pathway.

Table 1. Featured anti-BAD recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs uses state-of-the-art production technologies and years of antibody development experience to support the rapidly evolving research needs of signal transduction and cell biology. Our anti-BAD recombinant antibodies, especially our portfolio of phospho-specific BAD antibodies, are developed using proprietary immunization and screening methods to ensure highly specific reagents.

Featured Anti-BAD Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-BAD recombinant antibody production.

Fig.2 Gram-scale anti-BAD recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to empowering your research and discovery by providing antibodies that are customizable to fit your needs. Our anti-BAD recombinant antibodies are available in a variety of conjugations and formulations.

Fig.3 Full-length anti-BAD recombinant antibody production and modalities.

Dive deep into the mechanisms of the cell survival signaling program with the precision of Creative Biolabs' anti-BAD recombinant antibodies. Our extensive portfolio of anti-BAD antibodies, including a full suite of highly validated phospho-specific BAD antibodies, provides the perfect tools for your oncology and cell biology research. Choose quality you can trust to accelerate discovery. Contact our experts today.