Anti-CAMK2B Products

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Investigate the critical structural roles of CAMK2B with Creative Biolabs' recombinant antibodies. Defined by rigorous validation and exceptional consistency, our portfolio offers the ideal tools to study this key protein in neuronal development. Partner with us for quality that advances neuroscience. Contact our specialists today.

CAMK2B: A Kinase with Structural Roles at the Synapse

Calcium/Calmodulin-Dependent Protein Kinase II Beta (CAMK2B) is one of the two major isoforms of CAMKII in the brain, and it co-assembles with the alpha isoform into hetero-dodecamers. As with CAMK2A, this protein is a calcium-activated serine/threonine kinase that plays critical roles in mediating synaptic plasticity, with major effects on the structural plasticity of dendritic spines. CAMK2B has a unique linker region that enables binding directly to F-actin, providing a direct structural role in anchoring the kinase complex at the synapse and the regulation of dendritic spine morphology. Mutations in this gene have been identified as the cause of neurodevelopmental disorders, leading to intellectual disability and seizures.

Alternative Names

CAM2; CAMK2; CAMKB; MRD54; CaMKIIbeta

Background

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is important for several aspects of plasticity at glutamatergic synapses. The enzyme is likely to be a tetramer in mammalian cells and may be composed of four different chains (alpha, beta, gamma and delta). The product of this gene is one of the beta chains. There is a possibility that distinct isoforms of this gene have different cellular localizations and may interact differently with calmodulin. Multiple transcript variants have been found due to alternative splicing.

Anti-CAMK2B rAb Products

Our recombinant antibodies to CAMK2B are designed for optimal specificity and sensitivity to enable reliable detection of this key structural kinase. The reagents are carefully validated for specificity to the beta isoform in comparison to the alpha isoform. Optimized for super-resolution microscopy applications and biochemical pull-downs, these rAbs provide the specificity and precision you need to generate high-impact findings in cell biology.

Table 1. Featured anti-CAMK2B recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is committed to pushing the frontiers of neuroscience research. Our stringent quality control procedures guarantee that each batch of anti-CAMK2B recombinant antibody is rigorously validated for purity, binding affinity, and performance consistency. This ensures that you will receive a reliable, high-quality reagent that meets the precision requirements of studying structural mechanisms at the synapse.

Fig.1 IHC analysis of anti-CAMK2B antibody (Cat# ZG-0066J, Creative Biolabs).

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rAb Production

Creative Biolabs is pushing the boundaries of neuroscience research through the use of our next-generation production platforms. Our recombinant antibodies to CAMK2B are expressed in optimized systems to ensure that the resulting reagents accurately recognize the native protein. This process guarantees a product with the highest possible biological relevance.

Featured Anti-CAMK2B Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CAMK2B recombinant antibody production.

Fig.2 Gram-scale anti-CAMK2B recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing flexible, innovative solutions to meet the needs of neuroscience researchers around the world. Our recombinant antibodies to CAMK2B are available in a variety of customizable modalities, so you can choose the ideal formats for your investigation of this important regulator of neuronal structure and function.

Fig.3 Full-length anti-CAMK2B recombinant antibody production and modalities.

Explore the unique structural functions of CAMK2B in neuronal development and plasticity at the synapse with Creative Biolabs' recombinant antibodies. Our product line is defined by a rigorous validation process and exceptional consistency across all batches, so you can be confident that you will always receive the ideal tools to study this important protein. Partner with us for quality that will drive your progress. Contact our product specialists today.