Mouse Anti-CAMK2B Recombinant Antibody (VS3-FY2642) (CAT#: VS3-FY2642)
The mouse anti-CAMK2B recombinant monoclonal antibody has been genetically engineered to specifically target CAMK2 beta. The calculated molecular weight of the antigen is 72.7 kDa. It shows capability of cross-reacting with human, mouse and rat. This monoclonal antibody is potential for conducting research on Intellectual Developmental Disorder, Autosomal Dominant 54 and Autosomal Dominant Non-Syndromic Intellectual Disability. This monoclonal antibody can be used in Western Blot, Immunohistochemistry.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26307/57641_B_7_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26307/57641_B_7_5_val_selected.jpg
Figure 2 Low expression in pancreas
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26307/57641_A_1_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26307/57641_A_1_3_val_selected.jpg
Figure 3 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong nuclear and cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6849/ihc_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows strong nuclear and cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6849/ihc_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26307/57641_B_7_5.jpg
(Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26307/57641_B_7_5.jpg
Figure 5 Cerebellum
(Bergmann glia - cytoplasm/membrane Staining: Not detected Intensity: Negative Bergmann glia - nucleus Staining: Not detected Intensity: Negative GLUC cells - cytoplasm/membrane Staining: Not detected Intensity: Negative GLUC cells - nucleus Staining: Not detected Intensity: Negative Granular cells - cytoplasm/membrane Staining: Medium Intensity: Moderate Granular cells - nucleus Staining: Not detected Intensity: Negative Molecular layer - neuropil Staining: Medium Intensity: Moderate Molecular layer cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Molecular layer cells - nucleus Staining: Not detected Intensity: Negative Processes in granular layer Staining: Not detected Intensity: Negative Processes in molecular layer Staining: Not detected Intensity: Negative Processes in white matter Staining: Medium Intensity: Moderate Purkinje cells - cytoplasm/membrane Staining: High Intensity: Strong Purkinje cells - dendrites Staining: High Intensity: Strong Purkinje cells - nucleus Staining: Not detected Intensity: Negative Synaptic glomeruli - capsule Staining: Not detected Intensity: Negative Synaptic glomeruli - core Staining: High Intensity: Strong White matter cells - cytoplasm/membrane Staining: Medium Intensity: Moderate White matter cells - nucleus Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26307/57641_B_7_8.jpg
(Bergmann glia - cytoplasm/membrane Staining: Not detected Intensity: Negative Bergmann glia - nucleus Staining: Not detected Intensity: Negative GLUC cells - cytoplasm/membrane Staining: Not detected Intensity: Negative GLUC cells - nucleus Staining: Not detected Intensity: Negative Granular cells - cytoplasm/membrane Staining: Medium Intensity: Moderate Granular cells - nucleus Staining: Not detected Intensity: Negative Molecular layer - neuropil Staining: Medium Intensity: Moderate Molecular layer cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Molecular layer cells - nucleus Staining: Not detected Intensity: Negative Processes in granular layer Staining: Not detected Intensity: Negative Processes in molecular layer Staining: Not detected Intensity: Negative Processes in white matter Staining: Medium Intensity: Moderate Purkinje cells - cytoplasm/membrane Staining: High Intensity: Strong Purkinje cells - dendrites Staining: High Intensity: Strong Purkinje cells - nucleus Staining: Not detected Intensity: Negative Synaptic glomeruli - capsule Staining: Not detected Intensity: Negative Synaptic glomeruli - core Staining: High Intensity: Strong White matter cells - cytoplasm/membrane Staining: Medium Intensity: Moderate White matter cells - nucleus Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26307/57641_B_7_8.jpg
Figure 6 RNA cell line category: Cell line enriched (SCLC-21H)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000058404-CAMK2B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000058404-CAMK2B
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Calcium/calmodulin dependent protein kinase II beta of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 72.7 kDa.
- Related Disease
- Intellectual Developmental Disorder, Autosomal Dominant 54 and Autosomal Dominant Non-Syndromic Intellectual Disability
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunohistochemistry: 1/50-1/200
Target
- Alternative Names
- Calcium/Calmodulin Dependent Protein Kinase II Beta; Proline Rich Calmodulin-Dependent Protein Kinase; CaM Kinase II Beta Subunit; CaM-Kinase II Beta Chain; CaMK-II Subunit Beta; EC 2.7.11.17; CAMKB; CAMK2
- Gene ID
- 816
- UniProt ID
- Q13554
- Sequence Similarities
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
- Cellular Localization
- Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side
Synapse
- Post Translation Modifications
- Autophosphorylation of Thr-287 following activation by Ca(²⁺)/calmodulin.
Phosphorylation of Thr-287 locks the kinase into an activated state.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
Glycosylation from GlyGen 5 sites, 1 O-linked glycan (5 sites)
- Protein Refseq
- XP_005249919.1; XP_005249921.1; XP_006715844.1; XP_006715847.1; XP_011513849.1
- Function
- In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
Recommended Products
Secondary Antibody
Isotype Control
Related Resources
cAMP Signaling Pathway
Canonical Wnt Signaling Pathway
ErbB Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Amphetamine Addiction
Cushing Syndrome
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CAMK2B"
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3806z | Mouse Anti-CAMK2B Recombinant Antibody (clone 36D12) | ELISA, IHC, WB | Mouse IgG1, κ |
| MOB-0299CT | Mouse Anti-CAMK2B Recombinant Antibody (clone EML271) | IHC-P, WB | Mouse IgG1 |
| VS3-WK945 | Mouse Anti-CAMK2B Recombinant Antibody (VS3-WK945) | WB | Mouse IgG1 |
| VS3-WK1387 | Mouse Anti-CAMK2B Recombinant Antibody (VS3-WK1387) | IHC-p | Mouse IgG |
| VS3-FY183 | Recombinant Rabbit Anti-CAMK2B Antibody (clone R05-9G5) | WB | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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