CD133 & CD3
In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, Block, IHC-Fr, IF, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IP, IHC-P, FC, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, IHC-Fr, IHC-P, ICC, IP, WB, Activ, Block
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, Activ
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, IHC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, IHC
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- Species Reactivity: Mouse
- Type: Rat IgG2b, κ
- Application: FC, IHC, IP, Activ, CMCD, Depletion
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, IHC
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- Species Reactivity: Porcine
- Type: Mouse IgG2a, κ
- Application: ELISA, FuncS
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- Species Reactivity: Rhesus monkey
- Type: Mouse IgG, κ
- Application: ELISA, WB, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Fab fragment
- Application: ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized antibody
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Type: Humanized Antibody
- Application: ELISA, FC, FuncS
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Type: Humanized Antibody
- Application: ELISA, FC, FuncS
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- Type: Chimeric (mouse/human)
- Application: ELISA, FC, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Type: Chimeric (mouse/human)
- Application: ELISA, FC, FuncS
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- Application: IB, ELISA, FC, FuncS
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- Type: Humanized Antibody
- Application: ELISA, FC, FuncS
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- Type: Chimeric (mouse/human)
- Application: ELISA, FC, FuncS
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- Application: IP, IB, FuncS
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- Application: IB, ELISA, FC, FuncS
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- Application: FC, IB, ELISA
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- Application: IP, IB, FuncS
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Mouse IgG
- Application: ELISA
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