The anti-CD3 monoclonal antibody specifically target CD3 and can induce downmodulationg of the TCR/CD3 complex in mouse CD4+ T cells without activating T cells. Thus, the specific antbody can be used for suppressing immune responses and inducing immunosupression.
Figure 1 Recognition of CD3ε on mouse T cells by Dow2.
Suspensions of splenic pan-T cells from normal C57BL/6JJcl donors were used for flow cytometry analyses comparing the binding profiles of T cells incubated with Dow2 to T cells incubated with control anti-mouse CD3ε Abs 17A2 or 145-2C11 (1 μg/ml).
Sugita, S., Shimizu, J., Makabe, K., Keino, H., Watanabe, T., & Takahashi, M. (2017). Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody. Arthritis research & therapy, 19(1), 176.
Figure 2 Evaluation of ocular inflammation in experimental autoimmune uveitis (EAU) mice treated with Dow2 or rat IgG isotype control.
At 21 days postimmunization, the retinas of EAU mice were examined by FA, hematoxylin and eosin (H&E) staining of paraffin-embedded sections, and immunohistochemistry for CD3+ cells. Representative images are shown for immunohistochemistry of retinal sections (scale bar = 20 μm).
Sugita, S., Shimizu, J., Makabe, K., Keino, H., Watanabe, T., & Takahashi, M. (2017). Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody. Arthritis research & therapy, 19(1), 176.
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• High repeatability
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-118CL | Human Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-118CL) | ELISA | Fab fragment |
TAB-0418CL-S(P) | Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA, FC, FuncS | Humanized Antibody |
TAB-075LC-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-075LC-S(P)) | ELISA | Human scFv |
TAB-076LC-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-076LC-S(P)) | ELISA | Human scFv |
TAB-077LC-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-077LC-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0416CL | Anti-Human CD3 Recombinant Antibody (OKT3) | FC, IB, ELISA | |
TAB-0416CL-F(E) | Anti-Human CD3 Recombinant Antibody Fab Fragment (OKT3) | IB, ELISA, FC, FuncS | |
TAB-0422CL-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-0422CL-F(E)) | ELISA | Mouse Fab |
TAB-073LC | Mouse Anti-CD3 Recombinant Antibody (TAB-073LC) | ELISA, FC | Mouse IgG |
TAB-074LC | Mouse Anti-CD3 Recombinant Antibody (TAB-074LC) | ELISA, FC | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0417CL-S(P) | Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA, FC, FuncS | Chimeric (mouse/human) |
TAB-071LC-S(P) | Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
TAB-072LC-S(P) | Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
TAB-071LC-F(E) | Anti-Human CD3 Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
TAB-072LC-F(E) | Chimeric Anti-Human CD3 Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-339CQ | Mouse Anti-CD3 Recombinant Antibody (clone SPV-T3b) | FC, Block, IHC-Fr, IF, WB | Mouse IgG2a |
NEUT-340CQ | Mouse Anti-CD3 Recombinant Antibody (clone UCHT1) | FC, IHC-Fr, IHC-P, ICC, IP, WB, Activ, Block | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0043CQ | Mouse Anti-CD3 Recombinant Antibody (clone 898H2-6-15) | ELISA, FuncS | Mouse IgG2a, κ |
FAMAB-0044CQ | Mouse Anti-CD3 Recombinant Antibody (clone FN18) | ELISA, WB, FC, FuncS | Mouse IgG, κ |
HPAB-0672LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0672LY) | ELISA, FC | Mouse IgG1 |
HPAB-0673LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0673LY) | ELISA, FC | Mouse IgG1 |
HPAB-0674LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0674LY) | ELISA, FC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0667LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0667LY-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0668LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0668LY-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0669LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0669LY-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0670LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0670LY-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0671LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0671LY-F(E)) | ELISA, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0378-YC | Recombinant Llama Anti-CD3 Single Domain Antibody (A30228) | ELISA, FC | Llama VHH |
HPAB-M0379-YC | Recombinant Llama Anti-CD3 Single Domain Antibody (A30311) | ELISA, FC | Llama VHH |
HPAB-1029WJ | Recombinant Camelid Anti-CD3 Single Domain Antibody | ELISA | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1101-CN-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-1101-CN-S(P)) | ELISA, FC | Humanized scFv |
HPAB-0555-WJ-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-0555-WJ-S(P)) | ELISA | Human scFv |
HPAB-0441-YJ-S(P) | Mouse Anti-CD3 Recombinant Antibody (clone m3E3); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-0442-YJ-S(P) | Mouse Anti-CD3 Recombinant Antibody (clone hc3E3); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-1526WJ-S(P) | Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (clone 1D10) | ELISA, WB, FC | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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