Anti-Mouse CD3 Recombinant Antibody (Dow2)
CAT#: TAB-0365CL
The anti-CD3 monoclonal antibody specifically target CD3 and can induce downmodulationg of the TCR/CD3 complex in mouse CD4+ T cells without activating T cells. Thus, the specific antbody can be used for suppressing immune responses and inducing immunosupression.
Published Data
FC
Figure 1 Recognition of CD3ε on mouse T cells by Dow2.
Suspensions of splenic pan-T cells from normal C57BL/6JJcl donors were used for flow cytometry analyses comparing the binding profiles of T cells incubated with Dow2 to T cells incubated with control anti-mouse CD3ε Abs 17A2 or 145-2C11 (1 μg/ml).
Sugita, S., Shimizu, J., Makabe, K., Keino, H., Watanabe, T., & Takahashi, M. (2017). Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody. Arthritis research & therapy, 19(1), 176.
IHC
Figure 2 Evaluation of ocular inflammation in experimental autoimmune uveitis (EAU) mice treated with Dow2 or rat IgG isotype control.
At 21 days postimmunization, the retinas of EAU mice were examined by FA, hematoxylin and eosin (H&E) staining of paraffin-embedded sections, and immunohistochemistry for CD3+ cells. Representative images are shown for immunohistochemistry of retinal sections (scale bar = 20 μm).
Sugita, S., Shimizu, J., Makabe, K., Keino, H., Watanabe, T., & Takahashi, M. (2017). Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody. Arthritis research & therapy, 19(1), 176.
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Specifications
- Host Species
- Rat
- Specificity
- Mouse
- Clone
- Dow2
- Applications
- FC, IHC
Applications
- Application Notes
- The CD3 antibody has been reported in applications of Flow Cytometry, Immunohistochemistry.
Target
- Alternative Names
- CD3; CD3 T-Cell Co-receptor;CD3D; CD3E; CD3G
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This antibody comes with an extremely extensive datasheet. It had all the information needed to begin going, and the suggested methods operated flawlessly. beneficial to both novice and seasoned users.Comprehensive datasheet
This antibody comes with an extremely extensive datasheet. It had all the information needed to begin going, and the suggested methods operated flawlessly. beneficial to both novice and seasoned users.
For any lab, this is convenient because the antibody has an extended shelf life when maintained properly. We have been using it for a long time, and it has never lost its effectiveness.Long shelf life
For any lab, this is convenient because the antibody has an extended shelf life when maintained properly. We have been using it for a long time, and it has never lost its effectiveness.
The limited non-specific binding of this antibody is one of its finest qualities. The results are clear and accurate in both immunofluorescence and Western blotting, which is essential for exact data interpretation.Minimal non-specific binding
The limited non-specific binding of this antibody is one of its finest qualities. The results are clear and accurate in both immunofluorescence and Western blotting, which is essential for exact data interpretation.
Q&As
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In my research report, how should I reference this product?
A: Provide the product name, clone number, catalog number, and manufacturer in the materials and procedures section.
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Does the product's performance have a guarantee?
A: Most manufacturers offer replacements for products that don't meet specifications or meet performance guarantees.
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Does this product have an available certificate of analysis?
A: A certificate of authenticity (CoA) is typically provided, along with details on quality control parameters such as purity and activity.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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