Anti-Human CD3 Recombinant Antibody (VH1/VK1) (CAT#: TAB-085LC)
TAB-085LC is a recombinant monoclonal antibody targeting CD3. It is a humanized antibody with potential applications in treating autoimmune disorders, infectious diseases, and transplant rejection. This antibody is valuable in pharmaceutical use due to its humanized and de-immunized framework regions (FRs), which minimize the risk of a HAHA/HAMA response. Additionally, it enhances cell signaling activities to achieve positive immunological effects, while preserving cell-surface binding and preventing improper disulfide bond formation. Furthermore, it improves pharmaceutical stability.
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FC
Figure 1 Quantitative binding competition of humanized mAb variants with labeled OKT to Jurkat cells.
FuncS
Figure 2 T-cell proliferation assay of humanized MAbs
FuncS
Figure 3 IL-2 secretion assay of selected humanized mutants.
Figure 4 Stability study—comparison between humanized variant mAbs and OKT.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- VH1/VK1
- Applications
- ELISA, FC, FuncS
- Related Disease
- Autoimmune Disorders, infectious diseases, and Transplant rejection
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry and Functional Assay. Please see the Published Data for further information.
Target
- Alternative Names
- CD3; CD3 T-Cell Co-receptor;CD3D; CD3E; CD3G
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody
Mouse Antibody
Chimeric Antibody
Blocking Antibody
Recombinant Antibody
scFv Fragment Antibody
Fab Fragment Antibody
Single-domain Antibody
Agonistic Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-118CL | Human Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-118CL) | ELISA | Fab fragment |
| TAB-075LC-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-075LC-S(P)) | ELISA | Human scFv |
| TAB-076LC-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-076LC-S(P)) | ELISA | Human scFv |
| TAB-077LC-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-077LC-S(P)) | ELISA | Human scFv |
| TAB-078LC-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-078LC-S(P)) | ELISA | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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