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    EDAR

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    Anti-EDAR Products

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    For Research Use Only. Not For Clinical Use.


    This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
    Protein class

    Disease related genes, Human disease related genes, Plasma proteins

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (Squamous epithelial cells, Basal squamous epithelial cells, Macrophages)

    Immune cell specificity

    Group enriched (naive CD4 T-cell, naive CD8 T-cell)

    Cell line specificity

    Cell line enhanced (CAPAN-2, HaCaT, OE19)

    Interaction

    Binds to EDARADD. Associates with TRAF1, TRAF2, TRAF3 and NIK.

    Molecular function

    Developmental protein, Receptor

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