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    EFNB2

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
    EFNB2
    Protein class

    Cancer-related genes, Plasma proteins

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (Adipocytes, Hepatic stellate cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (AF22, OE19, SH-SY5Y)

    Interaction

    Interacts with PDZRN3 (By similarity). Binds to the receptor tyrosine kinases EPHA4, EPHB4 and EPHA3. (Microbial infection) Interacts with Hendra virus and Nipah virus G protein (PubMed:16007075, 16477309, 17376907, 15998730).

    Molecular function

    Developmental protein, Host cell receptor for virus entry, Receptor

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